18572974. IMPROVED BACILLUS PRODUCTION HOST simplified abstract (BASF SE)
Contents
IMPROVED BACILLUS PRODUCTION HOST
Organization Name
Inventor(s)
Max Fabian Felle of Ludwigshafen (DE)
Christopher Sauer of Ludwigshafen (DE)
Mathis Appelbaum of Ludwigshafen (DE)
Stefan Jenewein of Ludwigshafen (DE)
Tobias Klein of Kaiserlautern (DE)
Thomas Schweder of Greifswald (DE)
IMPROVED BACILLUS PRODUCTION HOST - A simplified explanation of the abstract
This abstract first appeared for US patent application 18572974 titled 'IMPROVED BACILLUS PRODUCTION HOST
The present invention involves a host cell designed to increase the production of biological compounds by decreasing biofilm components and increasing phosphorylated De-gll levels.
- Genetic modifications in the host cell lead to decreased biofilm production and increased De-gll phosphorylation.
- The host cell contains gene expression cassettes with polynucleotides encoding desired polypeptides linked to promoters for compound production.
- The method for increased polypeptide production involves cultivating the modified bacterial host cell.
Potential Applications:
- Biopharmaceutical production
- Industrial enzyme production
- Biofuel production
Problems Solved:
- Low production yields of biological compounds
- Inefficient host cell systems
Benefits:
- Increased production efficiency
- Enhanced yield of desired compounds
- Cost-effective manufacturing process
Commercial Applications:
- Biotechnology industry
- Pharmaceutical companies
- Research institutions
Questions about the technology: 1. How does the genetic modification in the host cell lead to increased production of biological compounds? 2. What are the specific benefits of using this modified host cell for compound production?
Original Abstract Submitted
The present invention relates to a host cell for increased production of biological compounds. Specifically, the invention relates to a host with genetic modifications that lead to decreased production of components of biofilm and increased levels of phosphorylated De-gll. Said host comprises at least one gene expression cassette with a polynucleotide encoding at least one polypeptide of interest, operably linked to a promoter for the production of compounds. The present invention further relates to a method for increased production of at least one polypeptide of interest based on cultivating the bacterial host cell of the present invention.
