18559667. PRODUCTION OF THERAPEUTIC MESENCHYMAL STEM CELL-DERIVED EXOSOMES simplified abstract (BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM)

PRODUCTION OF THERAPEUTIC MESENCHYMAL STEM CELL-DERIVED EXOSOMES

Organization Name

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor(s)

Frederick F. Lang of Houston TX (US)

Elizabeth J. Shpall of Houston TX (US)

Katy Rezvani of Houston TX (US)

Mayela Mendt of Houston TX (US)

Daniel Ledbetter of Houston TX (US)

Joy Gumin of Houston TX (US)

Brittany Parker Kerrigan of Houston TX (US)

Anwar Hossain of Houston TX (US)

Frederick M. Lang of Houston TX (US)

PRODUCTION OF THERAPEUTIC MESENCHYMAL STEM CELL-DERIVED EXOSOMES - A simplified explanation of the abstract

This abstract first appeared for US patent application 18559667 titled 'PRODUCTION OF THERAPEUTIC MESENCHYMAL STEM CELL-DERIVED EXOSOMES

Simplified Explanation: The patent application discusses systems, methods, and compositions for producing exosomes from mesenchymal stem cells and loading them with therapeutic agents.

• Exosomes can be produced from mesenchymal stem cells and loaded with therapeutic agents.
• An automated cell expansion system can be used to control the production of cells and exosomes.
• Exosomes can be harvested at specific times as part of a treatment regimen.
• Therapeutic agents can be loaded into exosomes using electroporation.
• The exosomes can be administered to individuals with medical disorders for therapeutic purposes.

Key Features and Innovation:

• Production of exosomes from mesenchymal stem cells.
• Loading exosomes with therapeutic agents.
• Use of an automated cell expansion system.
• Harvesting exosomes at specific times.
• Administration of exosomes to individuals with medical disorders.

Potential Applications: The technology can be used in regenerative medicine, drug delivery, and personalized medicine.

Problems Solved: The technology addresses the need for efficient production and delivery of therapeutic exosomes.

Benefits:

• Enhanced therapeutic potential of exosomes.
• Controlled production and delivery of exosomes.
• Personalized treatment options for individuals with medical disorders.

Commercial Applications: Potential commercial applications include pharmaceutical development, biotechnology research, and clinical therapy services.

Questions about Exosomes: 1. How do exosomes differ from other types of extracellular vesicles? 2. What are the challenges in scaling up the production of exosomes for therapeutic use?

Frequently Updated Research: Ongoing research focuses on optimizing the loading of exosomes with therapeutic agents and improving the targeting of exosomes to specific cell types.

Original Abstract Submitted

Aspects of the disclosure encompass systems, methods, and compositions for producing exosomes from mesenchymal stem cells and, optionally, loading said exosomes with one or more therapeutic agents. The systems, methods, and compositions may occur in an automated cell expansion system that allows for controllable parameters and from which cells and exosomes may be harvested at one or more times as part of a particular regimen. The exosomes may be loaded with one or more therapeutic agents using electroporation. In specific aspects, the exosomes may be provided to an individual in need thereof, including in some cases where the individual in need thereof is an individual having a medical disorder for which the exosomes would be therapeutic.