18553157. HUMAN PLURIPOTENT STEM CELL-DERIVED SECRETOME AS A BIOLOGIC FOR PREVENTION AND TREATMENT OF NEURODEGENERATIVE AND APOPTOTIC DISEASES simplified abstract (The Regents of the University of California)

HUMAN PLURIPOTENT STEM CELL-DERIVED SECRETOME AS A BIOLOGIC FOR PREVENTION AND TREATMENT OF NEURODEGENERATIVE AND APOPTOTIC DISEASES

Organization Name

The Regents of the University of California

Inventor(s)

Irina M. Conboy of El Sobrante CA (US)

Daehwan Kim of Albany CA (US)

Michael J. Conboy of El Sobrante CA (US)

HUMAN PLURIPOTENT STEM CELL-DERIVED SECRETOME AS A BIOLOGIC FOR PREVENTION AND TREATMENT OF NEURODEGENERATIVE AND APOPTOTIC DISEASES - A simplified explanation of the abstract

This abstract first appeared for US patent application 18553157 titled 'HUMAN PLURIPOTENT STEM CELL-DERIVED SECRETOME AS A BIOLOGIC FOR PREVENTION AND TREATMENT OF NEURODEGENERATIVE AND APOPTOTIC DISEASES

Simplified Explanation

The patent application discusses neuroprotective compositions and methods for protecting mammalian neurons from various harmful factors.

• Contacting cells with proteins secreted by induced pluripotent stem cells (iPSCs) can protect neurons from neurotoxins, oxidative stress, and other damaging conditions.

Key Features and Innovation

• Method involves using proteins secreted by iPSCs to protect neurons.
• Proteins are derived from healthy mammals or those with neurodegenerative diseases.
• Proteins are secreted when iPSC cells are pluripotent.
• Includes biologically active fragments and analogs of the proteins.

Potential Applications

The technology can be applied in the field of neuroprotection and potentially in the treatment of neurodegenerative diseases such as ALS.

Problems Solved

The technology addresses the need for effective neuroprotective strategies against various harmful factors that can damage neurons.

Benefits

• Protects mammalian neurons from neurotoxins, oxidative stress, and other damaging conditions.
• Offers potential therapeutic benefits for neurodegenerative diseases.
• Utilizes proteins secreted by iPSCs for neuroprotection.

Commercial Applications

Neuroprotective therapies for neurodegenerative diseases, pharmaceutical development for neuroprotection, and research in the field of neuronal health and protection.

Prior Art

Research on neuroprotective strategies using stem cell-derived proteins and their potential applications in neurodegenerative diseases.

Frequently Updated Research

Ongoing studies on the efficacy and mechanisms of action of iPSC-derived proteins in neuroprotection and their potential clinical applications.

Questions about Neuroprotective Compositions and Uses Thereof

What are the potential long-term implications of using iPSC-derived proteins for neuroprotection?

Using iPSC-derived proteins for neuroprotection could lead to novel therapeutic approaches for neurodegenerative diseases and potentially improve the quality of life for patients.

How do iPSC-derived proteins compare to other neuroprotective strategies currently available?

Compared to traditional neuroprotective strategies, iPSC-derived proteins offer a unique approach by utilizing natural proteins secreted by stem cells for neuronal protection.

Original Abstract Submitted

In various embodiments, neuroprotective compositions and uses thereof are provided. In certain embodiments, a method of protecting mammalian neurons from neurotoxins, oxidative stress or protein aggregation, mitochondrial dysfunction, inflammatory gene expression, induced cell death is provided where the method involves contacting the cells, such as neurons, with an effective amount of: a plurality of proteins that are secreted by induced pluripotent stem cells (iPSCs) derived from a healthy mammal and/or from a mammal with a disease, such as neurodegenerative pathology, exemplified by amyotrophic lateral sclerosis (ALS) where said proteins are secreted when said iPSC cells are pluripotent; and/or biologically active fragments of said proteins; and/or biologically active analogs of said proteins.