18551746. NANOCARRIERS FOR TARGETING TUMOR ASSOCIATED MACROPHAGES simplified abstract (OHIO STATE INNOVATION FOUNDATION)
Contents
- 1 NANOCARRIERS FOR TARGETING TUMOR ASSOCIATED MACROPHAGES
- 1.1 Organization Name
- 1.2 Inventor(s)
- 1.3 NANOCARRIERS FOR TARGETING TUMOR ASSOCIATED MACROPHAGES - A simplified explanation of the abstract
- 1.4 Simplified Explanation
- 1.5 Potential Applications
- 1.6 Problems Solved
- 1.7 Benefits
- 1.8 Potential Commercial Applications
- 1.9 Possible Prior Art
- 1.10 Original Abstract Submitted
NANOCARRIERS FOR TARGETING TUMOR ASSOCIATED MACROPHAGES
Organization Name
OHIO STATE INNOVATION FOUNDATION
Inventor(s)
Natalia Higuita-castro of Columbus OH (US)
Daniel Gallego-perez of Columbus OH (US)
Ana Salazar-puerta of Columbus OH (US)
NANOCARRIERS FOR TARGETING TUMOR ASSOCIATED MACROPHAGES - A simplified explanation of the abstract
This abstract first appeared for US patent application 18551746 titled 'NANOCARRIERS FOR TARGETING TUMOR ASSOCIATED MACROPHAGES
Simplified Explanation
The patent application describes a nanocarrier system using extracellular vesicles (EVs) loaded with therapeutic cargo to target tumor-associated macrophages (TAMs) for cancer treatment.
- Nanocarrier system utilizes custom-made EVs loaded with therapeutic cargo, such as antineoplastic agents.
- EVs are functionalized for targeted delivery by decorating them with ligands for specific receptors in TAMs.
Potential Applications
The technology can be applied in cancer treatment by targeting TAMs, which play a crucial role in tumor growth and metastasis.
Problems Solved
This innovation addresses the challenge of effectively targeting TAMs, which are often resistant to traditional cancer treatments.
Benefits
- Enhanced targeted delivery of therapeutic cargo to TAMs - Potential for improved cancer treatment outcomes - Reduced side effects compared to traditional treatments
Potential Commercial Applications
"Targeted Cancer Therapy Using Nanocarriers for TAMs"
Possible Prior Art
There may be prior art related to nanocarrier systems for targeted drug delivery in cancer treatment, but the specific use of EVs loaded with therapeutic cargo to target TAMs may be novel.
What is the mechanism of action of the nanocarrier system in targeting TAMs for cancer treatment?
The nanocarrier system works by utilizing extracellular vesicles (EVs) loaded with therapeutic cargo, such as antineoplastic agents, and decorating them with ligands for specific receptors in TAMs. This targeted approach allows for the selective delivery of therapeutic cargo to TAMs, inhibiting tumor growth and metastases.
How does the nanocarrier system compare to traditional cancer treatments in terms of efficacy and safety?
The nanocarrier system offers the potential for enhanced efficacy in cancer treatment by specifically targeting TAMs, which are known to promote tumor growth and metastasis. Additionally, by delivering therapeutic cargo directly to TAMs, the system may reduce off-target effects and improve safety compared to traditional treatments that affect both cancerous and healthy cells.
Original Abstract Submitted
Disclosed herein is a nanocarrier system to effectively target TAMs to treat cancer. The disclosed nanocarriers are custom-made extracellular vesicles (EVs) loaded with therapeutic cargo, such as antineoplastic agents, and are functionalized for targeted delivery via decoration with ligands for specific receptors in TAMs. Therefore, also disclosed is a method of inhibiting tumor growth or tumor metastases in a subject in need thereof comprising selectively targeting TAMs.
