18541658. Vitro Production of Medial Ganglionic Eminence Precursor Cells simplified abstract (The Regents of the University of California)
Contents
Vitro Production of Medial Ganglionic Eminence Precursor Cells
Organization Name
The Regents of the University of California
Inventor(s)
Cory R. Nicholas of San Francisco CA (US)
John L. Rubenstein of San Francisco CA (US)
Arnold R. Kriegstein of Mill Valley CA (US)
Arturo Alvarez-buylla of Woodside CA (US)
Vitro Production of Medial Ganglionic Eminence Precursor Cells - A simplified explanation of the abstract
This abstract first appeared for US patent application 18541658 titled 'Vitro Production of Medial Ganglionic Eminence Precursor Cells
Simplified Explanation: The patent application describes methods and systems for generating precursor cells for medial ganglionic eminence (MGE) in vitro, leading to the production of functional MGE precursors that differentiate into GABAergic interneurons.
- Efficient production of MGE precursor cells
- Functional MGE precursors that differentiate into GABAergic interneurons
Potential Applications: This technology could be used in regenerative medicine for treating neurological disorders, such as epilepsy and schizophrenia, by replacing damaged or dysfunctional GABAergic interneurons.
Problems Solved: This technology addresses the challenge of efficiently producing functional MGE precursor cells that can differentiate into GABAergic interneurons, which are crucial for neural circuit function.
Benefits: The technology offers a potential solution for neurological disorders by providing a source of functional GABAergic interneurons for transplantation or research purposes.
Commercial Applications: "Generating Functional MGE Precursor Cells for Neural Regeneration"
This technology has commercial applications in the biotechnology and pharmaceutical industries for developing cell-based therapies for neurological disorders.
Prior Art: Prior research has focused on generating GABAergic interneurons from various precursor cell types, but the efficiency and functionality of these cells have been limited.
Frequently Updated Research: Ongoing research is focused on optimizing the differentiation protocols for MGE precursor cells to enhance their functionality and integration into neural circuits.
Questions about MGE Precursor Cells: 1. How do MGE precursor cells differ from other types of neural precursor cells? 2. What are the potential challenges in translating this technology into clinical applications?
Original Abstract Submitted
Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons.
