18444966. Protein Engineering via Error-Prone Orthogonal Replication and Yeast Surface Display simplified abstract (The Regents of the University of California)

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Protein Engineering via Error-Prone Orthogonal Replication and Yeast Surface Display

Organization Name

The Regents of the University of California

Inventor(s)

Chang C. Liu of Irvine CA (US)

Alon Wellner of Irvine CA (US)

Ziwei Zhong of Irvine CA (US)

Arjun Ravikumar of Irvine CA (US)

Andrew Kruse of Boston MA (US)

Conor Thomas Mcmahon of Brighton MA (US)

Protein Engineering via Error-Prone Orthogonal Replication and Yeast Surface Display - A simplified explanation of the abstract

This abstract first appeared for US patent application 18444966 titled 'Protein Engineering via Error-Prone Orthogonal Replication and Yeast Surface Display

Abstract: Disclosed herein are methods, compositions, and kits for engineering proteins using error-prone orthogonal replication (epOrthoRep) and yeast surface display (YSD).

  • Simplified Explanation: The patent application discusses techniques for protein engineering using epOrthoRep and YSD.
  • Key Features and Innovation:

- Utilizes error-prone orthogonal replication for protein engineering. - Incorporates yeast surface display for protein manipulation. - Provides methods, compositions, and kits for these processes.

  • Potential Applications:

- Biopharmaceutical development. - Industrial enzyme production. - Protein structure-function studies.

  • Problems Solved:

- Enhancing protein engineering efficiency. - Facilitating the manipulation of proteins. - Improving the development of novel proteins.

  • Benefits:

- Increased diversity in protein engineering. - Streamlined protein manipulation processes. - Accelerated development of protein-based products.

  • Commercial Applications:

- Biotechnology companies for protein engineering. - Pharmaceutical companies for drug development. - Research institutions for protein studies.

  • Prior Art: The patent application may reference prior art related to protein engineering, error-prone replication, and yeast surface display techniques.
  • Frequently Updated Research: Stay updated on advancements in protein engineering, error-prone replication, and yeast surface display technologies to enhance understanding and application of the disclosed methods.

Questions about protein engineering using epOrthoRep and YSD: 1. How does error-prone orthogonal replication improve protein engineering processes? 2. What are the potential limitations of utilizing yeast surface display in protein manipulation?


Original Abstract Submitted

Disclosed herein are methods, compositions, and kits for engineering proteins using error-prone orthogonal replication (epOrthoRep) and yeast surface display (YSD).