18435544. METHODS FOR MAKING L-GLUFOSINATE simplified abstract (BASF SE)
Contents
METHODS FOR MAKING L-GLUFOSINATE
Organization Name
Inventor(s)
Brian Michael Green of Lutherville MD (US)
Michelle Lorraine Gradley of Canterbury (GB)
METHODS FOR MAKING L-GLUFOSINATE - A simplified explanation of the abstract
This abstract first appeared for US patent application 18435544 titled 'METHODS FOR MAKING L-GLUFOSINATE
The patent application describes methods for the production of L-glufosinate, also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid, through a two-step process.
- The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid).
- The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors.
- By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
Potential Applications: - Production of L-glufosinate for agricultural use as a herbicide. - Pharmaceutical applications for L-glufosinate in the treatment of certain medical conditions.
Problems Solved: - Efficient production of L-glufosinate from D-glufosinate. - Increased purity of L-glufosinate in the final product.
Benefits: - Higher yield of L-glufosinate. - Improved cost-effectiveness in the production process.
Commercial Applications: - Agricultural industry for herbicide production. - Pharmaceutical industry for drug development.
Questions about the technology: 1. How does the specific amination process improve the purity of L-glufosinate? 2. What are the potential environmental implications of using L-glufosinate as a herbicide?
Frequently Updated Research: - Stay updated on advancements in the production of L-glufosinate for potential improvements in efficiency and yield.
Original Abstract Submitted
Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
