18398557. METHODS AND COMPOSITIONS FOR INHIBITING FIBROBLAST ACTIVATION simplified abstract (NOVOCURE GMBH)
Contents
METHODS AND COMPOSITIONS FOR INHIBITING FIBROBLAST ACTIVATION
Organization Name
Inventor(s)
Anat Klein-goldberg of Haifa (IL)
Tali Voloshin-sela of Haifa (IL)
METHODS AND COMPOSITIONS FOR INHIBITING FIBROBLAST ACTIVATION - A simplified explanation of the abstract
This abstract first appeared for US patent application 18398557 titled 'METHODS AND COMPOSITIONS FOR INHIBITING FIBROBLAST ACTIVATION
The patent application describes methods for treating subjects with cancer by applying an alternating electric field to a target site and administering a cancer-associated fibroblast (CAF) inhibitor.
- Applying alternating electric fields to cells containing fibroblasts to reduce or prevent CAF activation.
- Contacting a CAF activation inhibitor to the cell population to inhibit CAF signaling.
- Applying alternating electric fields to cells containing fibroblasts to reduce CAF signaling.
- Contacting a CAF signaling inhibitor to the cell population to inhibit CAF signaling.
Potential Applications: - Treatment of cancer by targeting CAFs. - Prevention of CAF activation in cancer patients.
Problems Solved: - Addressing the role of CAFs in cancer progression. - Providing a novel approach to cancer treatment by targeting CAFs.
Benefits: - Improved efficacy in cancer treatment. - Potential for reducing tumor growth and metastasis.
Commercial Applications: - Development of new cancer therapies targeting CAFs. - Potential for pharmaceutical companies to develop CAF inhibitors.
Questions about the technology: 1. How do alternating electric fields affect CAF activation? 2. What are the potential side effects of CAF inhibitors in cancer treatment?
Frequently Updated Research: - Stay updated on the latest advancements in CAF-targeted cancer therapies.
Original Abstract Submitted
Disclosed are methods of treating a subject in need thereof comprising applying an alternating electric field, to a target site of the subject in need thereof; and administering a cancer associated fibroblast (CAF) inhibitor to the subject in need thereof. Disclosed are methods of reducing or preventing CAF activation comprising applying alternating electric fields, to a population of cells comprising one or more fibroblasts; and contacting a CAF activation inhibitor to the population of cells. Disclosed are methods of reducing CAF signaling comprising applying alternating electric fields, to a population of cells comprising one or more fibroblasts; and contacting a cancer associated fibroblast (CAF) signaling inhibitor to the population of cells.
