18214841. AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME simplified abstract (The Regents of the University of California)

AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME

Organization Name

The Regents of the University of California

Inventor(s)

Jerry Yang of La Jolla CA (US)

Emmanuel A. Theodorakis of San Diego CA (US)

Stella Sarraf of Beverly Hills CA (US)

AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME - A simplified explanation of the abstract

This abstract first appeared for US patent application 18214841 titled 'AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME

The patent application describes the design and synthesis of novel molecular rotor fluorophores for detecting amyloid or amyloid-like proteins, with enhanced fluorescence emission upon association with these proteins.

• The molecular rotor fluorophores are designed to exhibit increased fluorescence emission when bound to amyloid or amyloid-like proteins compared to when unbound.
• The technology includes methods for treating diseases associated with amyloid or amyloid-like proteins.
• The innovation aims to improve the detection and treatment of conditions related to amyloid proteins.
• The molecular rotor fluorophores have potential applications in medical diagnostics and research related to amyloidosis.
• This technology addresses the need for more sensitive and specific methods for detecting and targeting amyloid or amyloid-like proteins.

Questions about Molecular Rotor Fluorophores: 1. How do molecular rotor fluorophores enhance the detection of amyloid proteins?

  - Molecular rotor fluorophores are designed to emit more fluorescence when bound to amyloid proteins, allowing for easier detection.

2. What are the potential applications of molecular rotor fluorophores beyond amyloid detection?

  - Molecular rotor fluorophores could potentially be used in various medical diagnostic applications beyond amyloidosis detection.

Original Abstract Submitted

Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.