Robert bosch gmbh (20240240172). Process for Purifying Nucleic Acids, in particular in a Microfluidic Apparatus simplified abstract
Contents
Process for Purifying Nucleic Acids, in particular in a Microfluidic Apparatus
Organization Name
Inventor(s)
Tanja Maucher of Stuttgart (DE)
Christian Grumaz of Waiblingen (DE)
Martina Budde of Karlsruhe (DE)
Process for Purifying Nucleic Acids, in particular in a Microfluidic Apparatus - A simplified explanation of the abstract
This abstract first appeared for US patent application 20240240172 titled 'Process for Purifying Nucleic Acids, in particular in a Microfluidic Apparatus
Simplified Explanation:
This patent application discloses a method for purifying nucleic acids, particularly in a microfluidic apparatus. The method involves releasing nucleic acids from a sample using chaotrope substances in a transport medium and binding the nucleic acids to a filter, with the transport medium mixed with a wash buffer to adjust binding conditions. A microfluidic kit for implementing the method is also described.
- Key Features and Innovation:
- Purification of nucleic acids in a microfluidic system. - Use of chaotrope substances to release nucleic acids from samples. - Binding nucleic acids to a filter for purification. - Adjustment of binding conditions by mixing transport medium with a wash buffer. - Provision of a microfluidic kit for carrying out the purification process.
- Potential Applications:
- Biomedical research laboratories. - Clinical diagnostics for genetic testing. - Forensic analysis for DNA profiling. - Environmental testing for microbial identification. - Pharmaceutical industry for drug development.
- Problems Solved:
- Efficient purification of nucleic acids. - Simplified process for handling nucleic acid samples. - Compatibility with microfluidic systems. - Enhanced sensitivity and accuracy in nucleic acid analysis. - Reduction of contamination risks during purification.
- Benefits:
- Faster and more reliable nucleic acid purification. - Increased throughput in sample processing. - Improved quality of nucleic acid samples. - Cost-effective method for purification. - Automation potential for high-throughput applications.
- Commercial Applications:
- Title: "Microfluidic Nucleic Acid Purification Method for Biomedical and Diagnostic Applications" - Potential commercial uses in research institutions, diagnostic laboratories, and biotechnology companies. - Market implications include improved efficiency in nucleic acid analysis, leading to faster results and better data quality.
- Prior Art:
- Readers can explore prior patents related to microfluidic nucleic acid purification methods, chaotrope substances in nucleic acid extraction, and filter-based nucleic acid purification techniques.
- Frequently Updated Research:
- Stay informed about advancements in microfluidic technologies for nucleic acid purification. - Follow developments in chaotrope-based methods for releasing nucleic acids from samples. - Monitor innovations in filter materials and designs for nucleic acid binding and purification.
Questions about Nucleic Acid Purification in Microfluidic Systems: 1. How does the use of chaotrope substances improve nucleic acid purification efficiency in microfluidic systems? 2. What are the potential challenges in scaling up this method for high-throughput applications?
Original Abstract Submitted
a method for purifying nucleic acids, in particular in a microfluidic apparatus, is disclosed. the method includes releasing nucleic acids from a sample by way of chaotrope substances in a transport medium and binding the nucleic acids to a filter, the transport medium being mixed with a first portion of a wash buffer in order to adjust the binding conditions. a microfluidic kit for carrying out the method is further disclosed.