18648653. DUAL SPECIFIC ANTIBODIES simplified abstract (GENENTECH, INC.)
Contents
DUAL SPECIFIC ANTIBODIES
Organization Name
Inventor(s)
Germaine Fuh of Pacifica CA (US)
Chingwei V. Lee of Foster City CA (US)
Patrick Koenig of San Francisco CA (US)
DUAL SPECIFIC ANTIBODIES - A simplified explanation of the abstract
This abstract first appeared for US patent application 18648653 titled 'DUAL SPECIFIC ANTIBODIES
The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having specific characteristics and altering the nucleic acid sequence encoding certain residues in the antibody. The altered antibodies are then selected for their dual specificity.
- Identification of a monospecific antibody with specific characteristics
- Alteration of nucleic acid sequence encoding certain residues in the antibody
- Selection of altered antibodies for dual specificity
- Generation of dual specific antibodies or antigen-binding fragments
- Methods of using the antibodies
Potential Applications: - Biomedical research - Therapeutic treatments - Diagnostic tools
Problems Solved: - Enhancing antibody specificity - Improving targeted therapy - Advancing research in immunology
Benefits: - Increased precision in targeting antigens - Enhanced efficacy in treatment - Potential for personalized medicine
Commercial Applications: Title: "Innovative Dual Specific Antibodies for Biomedical Applications" This technology could revolutionize the field of antibody therapy and diagnostics, leading to new commercial opportunities in the healthcare industry.
Questions about Dual Specific Antibodies: 1. How do dual specific antibodies differ from traditional antibodies? Dual specific antibodies have the ability to bind to two different antigens simultaneously, offering enhanced targeting capabilities. 2. What are the potential challenges in developing dual specific antibodies for commercial use? Developing dual specific antibodies may require extensive research and validation to ensure safety and efficacy in clinical applications.
Original Abstract Submitted
The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region Vresidues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the Vof the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the Vof the antibody. The altered Vand the Vare expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected. Exemplary dual specific antibodies are also provided as well as methods of using the antibodies.
