IL4I1 INHIBITORS AND METHODS OF USE

The invention describes a method for synthesizing benzimidazole derivatives and intermediates using aryl halides and primary amines, with specific additives and catalysts.

Proceeding arylation between aryl halide and primary amine
Using L-pro as an additive and cuprous iodide as a catalyst
Conducting molecular arylation coupling reaction for aryl iodide or aryl bromide and primary amine
Starting with iodo phenylamine compound and bromophenylamine compound
Synthesizing the material through several-step transformation

Key Features and Innovation

Utilizes specific additives and catalysts for efficient synthesis
Involves molecular arylation coupling reactions for specific compounds
Offers a method for synthesizing benzimidazole derivatives and intermediates

Potential Applications

The method can be used in pharmaceutical research for developing new drugs, as benzimidazole derivatives have various biological activities.

Problems Solved

Provides a streamlined process for synthesizing benzimidazole derivatives and intermediates, potentially reducing time and resources required.

Benefits

Efficient and effective method for synthesizing benzimidazole derivatives
Potential for discovering new pharmaceutical compounds

Commercial Applications

Pharmaceutical industry for drug development
Chemical industry for production of specialty compounds

Prior Art

Readers can explore prior research on benzimidazole derivatives and related synthesis methods in academic journals and patent databases.

Frequently Updated Research

Stay updated on advancements in benzimidazole derivative synthesis and related pharmaceutical applications through scientific publications and industry conferences.

Questions about Benzimidazole Derivative Synthesis

What are the key additives and catalysts used in the synthesis process?

The key additives include L-pro, and the catalyst is cuprous iodide.

How can this method benefit the pharmaceutical industry?

This method can streamline the synthesis of benzimidazole derivatives, potentially leading to the discovery of new drugs with various biological activities.

Original Abstract Submitted

The invention discloses a synthesizing method of benzimidazole derivant and intermediate, which is characterized by the following: proceeding arylation among aryl halide and primary amine; adopting L-pro as additive, cuprous iodide as catalyst; proceeding molecular arylation coupling reaction for aryl iodide or aryl bromide and primary amine; adopting iodo phenylamine compound and bromophenylamine compound as starting material; synthesizing the material through several-step transformation.

18556196. IL4I1 INHIBITORS AND METHODS OF USE simplified abstract (Merck Sharp & Dohme LLC)

Contents

IL4I1 INHIBITORS AND METHODS OF USE

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