20250215084. Antigen Binding (Immatics Biotechnologies)
ANTIGEN BINDING PROTEINS SPECIFICALLY BINDING MAGE-A
Abstract: the present invention concerns antigen binding proteins specifically binding melanoma associated antigen a (mage-a) protein-derived antigens. the invention in particular provides antigen binding proteins which specifically bind to the mage-a antigenic peptide comprising or consisting of seq id no: 1 in a complex with a major histocombatibility (mhc) protein. the antigen binding proteins of the invention contain, in particular, the complementary determining regions (cdrs) of novel engineered t cell receptors (tcrs) that specifically bind to said mage-a peptide/mhc complex. the antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of mage-a expressing cancerous diseases. further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.
Inventor(s): Meike HUTT, Felix UNVERDORBEN, Sebastian BUNK, Dominik MAURER, Martin HOFMANN, Gabriele PSZOLLA, Sara YOUSEF, Claudia WAGNER, Frank SCHWOEBEL, Heiko SCHUSTER
CPC Classification: C07K16/2809 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))
Search for rejections for patent application number 20250215084
- Patent Applications
- Immatics Biotechnologies GmbH
- CPC C07K16/2809
- Meike HUTT of Tübingen DE
- Felix UNVERDORBEN of Tübingen DE
- Sebastian BUNK of Tübingen DE
- Dominik MAURER of Tübingen DE
- Martin HOFMANN of Tübingen DE
- Gabriele PSZOLLA of Tübingen DE
- Sara YOUSEF of Tübingen DE
- Claudia WAGNER of Tübingen DE
- Frank SCHWOEBEL of Tübingen DE
- Heiko SCHUSTER of Tübingen DE