STABILIZATION OF NAD(P)-DEPENDENT SENSOR WITH NEGATIVELY CHARGED MEMBRANE

Abstract: the present disclosure provides analyte sensors comprising a sensing layer disposed upon a surface of a first working electrode, wherein the sensing layer comprises an nad(p)-dependent enzyme and a supply of nad(p); and a multilayered membrane that overcoats at least a part of the sensing layer and is permeable to an analyte, wherein the membrane comprises at least one layer of negatively charged polymer. the present disclosure also provides methods of using such analyte sensors for detecting one or more analytes preset in a biological sample and methods of manufacturing the analyte sensors.

Inventor(s): Tianmei OUYANG, Yagya R. OJHA, Lindsey PELSTER, Benjamin FELDMAN, Jonathan D. MCCANLESS, Ahmed Hisham WALI

CPC Classification: A61B5/14546 (Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; {Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue} (measuring of blood pressure or blood flow ; non-radiation detecting or locating of foreign bodies in blood ))

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