METHOD FOR REDUCING ENDOTOXIN LEVELS IN NUCLEIC ACID PURIFICATION

Abstract: the present invention relates to a method for reducing endotoxin levels or removing endotoxins from nucleic acids. for this a zwitterionic detergent selected from the group of amine oxides or mixtures thereof is added during anion exchange chromatographic purification of the nucleic acids using a membrane or monolith-based sorbent.

Inventor(s): Anja HEINEN-KREUZIG, Andre KIESEWETTER, Herbert LUTZ, Akshat GUPTA

CPC Classification: C12N15/101 ({by chromatography, e.g. electrophoresis, ion-exchange, reverse phase})

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