18684234. METHODS FOR IN VITRO EVALUATION USING FUNCTIONAL ENGINEERED THREE-DIMENSIONAL TISSUES WITH CIRCUMFERENTIAL OR HELICALLY ORIENTED TISSUE STRUCTURE (President and Fellows of Harvard College)

METHODS FOR IN VITRO EVALUATION USING FUNCTIONAL ENGINEERED THREE-DIMENSIONAL TISSUES WITH CIRCUMFERENTIAL OR HELICALLY ORIENTED TISSUE STRUCTURE

Organization Name

President and Fellows of Harvard College

Inventor(s)

John F. Zimmerman of Boston MA US

Huibin Chang of Cambridge MA US

Kevin Kit Parker of Cambridge MA US

METHODS FOR IN VITRO EVALUATION USING FUNCTIONAL ENGINEERED THREE-DIMENSIONAL TISSUES WITH CIRCUMFERENTIAL OR HELICALLY ORIENTED TISSUE STRUCTURE

This abstract first appeared for US patent application 18684234 titled 'METHODS FOR IN VITRO EVALUATION USING FUNCTIONAL ENGINEERED THREE-DIMENSIONAL TISSUES WITH CIRCUMFERENTIAL OR HELICALLY ORIENTED TISSUE STRUCTURE

Original Abstract Submitted

Methods of evaluating functional activity of an engineered three-dimensional tissue, methods of identifying a compound that modulates tissue function, and methods for identifying a compounds that is useful for treating or preventing a disease affecting tissue function are provided herein. Some methods include providing or obtaining a three-dimensional tissue scaffold defining a lumen or a cavity, the tissue scaffold comprising one or more polymeric fibers each having a micron-scale or nanometer-scale diameter, at least some of the one or more polymeric fibers encircling the lumen or cavity at a helical angle with respect to a longitudinal axis of the lumen or cavity, at an azimuthal orientation with respect to the longitudinal axis of the lumen or cavity, or at both.