18741056. MULTICOMPONENT DEGRADABLE CATIONIC POLYMERS (The Johns Hopkins University)
MULTICOMPONENT DEGRADABLE CATIONIC POLYMERS
Organization Name
Inventor(s)
Jordan J. Green of Columbia MD US
Joel C. Sunshine of Baltimore MD US
Nupura S. Bhise of Baltimore MD US
Ron B. Shmueli of Baltimore MD US
Stephany Y. Tzeng of Baltimore MD US
MULTICOMPONENT DEGRADABLE CATIONIC POLYMERS
This abstract first appeared for US patent application 18741056 titled 'MULTICOMPONENT DEGRADABLE CATIONIC POLYMERS
Original Abstract Submitted
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
- The Johns Hopkins University
- Jordan J. Green of Columbia MD US
- Joel C. Sunshine of Baltimore MD US
- Nupura S. Bhise of Baltimore MD US
- Ron B. Shmueli of Baltimore MD US
- Stephany Y. Tzeng of Baltimore MD US
- C08F222/10
- A61K9/107
- A61K31/713
- A61K38/02
- A61K47/20
- A61K48/00
- C07C229/12
- C07C323/25
- C08G73/02
- C12N15/88
- CPC C08F222/102