18901582. PHOTOREDOX METHODS FOR RADIOCYANATION OF ARENES AND USE THEREOF (The University of North Carolina at Chapel Hill)

PHOTOREDOX METHODS FOR RADIOCYANATION OF ARENES AND USE THEREOF

Organization Name

The University of North Carolina at Chapel Hill

Inventor(s)

Zibo Li of Chapel Hill NC US

David Nicewicz of Durham NC US

Xuedan Wu of Apex NC US

PHOTOREDOX METHODS FOR RADIOCYANATION OF ARENES AND USE THEREOF

This abstract first appeared for US patent application 18901582 titled 'PHOTOREDOX METHODS FOR RADIOCYANATION OF ARENES AND USE THEREOF

Original Abstract Submitted

Carbon is one of the most common elements in bioactive organic compounds. Theoretically, nearly all carbon-based organic functional groups can be labeled with C if an appropriate C-synthon is developed and utilized. Although there are various reports on developing PET agents based on alkyl [C]nitriles, efficient and facile cyanation of arenes with radioisotope-containing reagents, particularly electron-rich arenes, still requires further improvements. The organic photoredox-catalyzed cyanation method reported herein introduces a [C]nitrile quickly with high radiochemical conversion (RCC) in a metal-free manner, which can also be further diversified to other functional groups such as [C]carboxylic acids, [C]amides, and [C]alkyl amines.