18293683. INHIBITORS OF HYPOXIA-INDUCIBLE FACTORS (THE JOHNS HOPKINS UNIVERSITY)
INHIBITORS OF HYPOXIA-INDUCIBLE FACTORS
Organization Name
Inventor(s)
Gregg L. Semenza of Reisterstown MD US
Akrit Sodhi of Cockeysville MD US
Shaima Salman of Baltimore MD US
David J. Meyers of Towson MD US
Yousang Hwang of Baltimore MD US
INHIBITORS OF HYPOXIA-INDUCIBLE FACTORS
This abstract first appeared for US patent application 18293683 titled 'INHIBITORS OF HYPOXIA-INDUCIBLE FACTORS
Original Abstract Submitted
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt thereof) used to treat a condition or disease that is associated with hypoxia, or with increased expression of hypoxia-inducible factor HIF-1 and/or HIF-2, or with both, the method comprising administering to a subject in need of such treatment a compound of Formula (I) that is capable of inhibiting transcriptional activation mediated by HIFs. This disclosure also features compositions containing the same as well as methods of using and making the same.