AMGEN INC. (20250011779). COMPOSITIONS AND METHODS FOR ENHANCING GENE SILENCING ACTIVITY OF OLIGONUCLEOTIDE COMPOUNDS
COMPOSITIONS AND METHODS FOR ENHANCING GENE SILENCING ACTIVITY OF OLIGONUCLEOTIDE COMPOUNDS
Organization Name
Inventor(s)
Jiamiao Lu of Mountain View CA US
Michael Ollmann of San Carlos CA US
Patrick Collins of Millbrae CA US
Chi-Ming Li of Thousand Oaks CA US
Songli Wang of Palo Alto CA US
COMPOSITIONS AND METHODS FOR ENHANCING GENE SILENCING ACTIVITY OF OLIGONUCLEOTIDE COMPOUNDS
This abstract first appeared for US patent application 20250011779 titled 'COMPOSITIONS AND METHODS FOR ENHANCING GENE SILENCING ACTIVITY OF OLIGONUCLEOTIDE COMPOUNDS
Original Abstract Submitted
the present invention relates to compositions and methods for enhancing the gene silencing activity of oligonucleotide compounds. in particular, the invention relates to inhibiting the expression or activity of suppressor proteins, such as rab18, zw10, stx18, scfd2, napg, samd4b, or vps37a, to increase the efficacy of ligand-conjugated oligonucleotide compounds in reducing the expression of target genes in a cell.
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