18967512. METHOD FOR OBTAINING ANTIBODY SEQUENCE (BEIJING BAIDU NETCOM SCIENCE TECHNOLOGY CO., LTD.)

METHOD FOR OBTAINING ANTIBODY SEQUENCE

Organization Name

BEIJING BAIDU NETCOM SCIENCE TECHNOLOGY CO., LTD.

Inventor(s)

Jie Gao of Beijing CN

Jing Hu of Beijing CN

Xiaomin Fang of Beijing CN

Xiaonan Zhang of Beijing CN

METHOD FOR OBTAINING ANTIBODY SEQUENCE

This abstract first appeared for US patent application 18967512 titled 'METHOD FOR OBTAINING ANTIBODY SEQUENCE

Original Abstract Submitted

A method for obtaining an antibody sequence includes: obtaining first features of amino acids at different sequence positions according to an antigen multiple sequence alignment (MSA) sequence, an antibody MSA sequence, and a concatenated sequence of the antigen MSA sequence and the antibody MSA sequence; obtaining second feature of the amino acids at different 3D coordinates according to a graph constructed according to a reference antigen-antibody complex; fusing the first features of amino acids at different sequence positions with the second features of amino acids at 3D coordinates corresponding to the different sequence positions, and obtaining probability information of each of the amino acids at different positions in the antibody sequence according to fused features; and obtaining a target antibody sequence according to the amino acids and their probability information at different positions in the antibody sequence.