20240041011. INFECTIOUS DISEASE MOUSE MODELS simplified abstract (The Jackson Laboratory)

INFECTIOUS DISEASE MOUSE MODELS

Organization Name

The Jackson Laboratory

Inventor(s)

James Keck of Granite Bay (CA)

INFECTIOUS DISEASE MOUSE MODELS - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240041011 titled 'INFECTIOUS DISEASE MOUSE MODELS

Simplified Explanation

The abstract of the patent application describes immunodeficient mouse models that are engrafted with cells containing a pathogen entry moiety, specifically for assessing pathogenic infections, particularly respiratory viruses.

• The patent application describes immunodeficient mouse models.
• These models are engrafted with cells that have a pathogen entry moiety.
• The purpose of these models is to assess pathogenic infections, specifically respiratory viruses.

Potential Applications:

• Research and development of antiviral drugs and vaccines.
• Understanding the mechanisms of pathogenic infections and host immune responses.
• Testing the efficacy of various treatments and interventions for respiratory viral infections.

Problems Solved:

• Lack of suitable animal models for studying pathogenic infections, especially respiratory viruses.
• Difficulty in assessing the effectiveness of potential treatments and interventions.
• Limited understanding of the host immune response to respiratory viral infections.

Benefits:

• Improved understanding of pathogenic infections and host immune responses.
• Enhanced ability to develop effective antiviral drugs and vaccines.
• More accurate assessment of treatment efficacy and intervention strategies.

Original Abstract Submitted

provided herein are immnunodeficient mouse models engrafted with cells comprising a pathogen entry moiety, for example, for assessing pathogenic infection. the pathogen may be a virus, such as a respiratory virus.