18675023. OLIGONUCLEOTIDES FOR TISSUE SPECIFIC GENE EXPRESSION MODULATION (University of Massachusetts)
Contents
OLIGONUCLEOTIDES FOR TISSUE SPECIFIC GENE EXPRESSION MODULATION
Organization Name
Inventor(s)
Anastasia Khvorova of Westborough MA (US)
Chantal Ferguson of Worcester MA (US)
OLIGONUCLEOTIDES FOR TISSUE SPECIFIC GENE EXPRESSION MODULATION
This abstract first appeared for US patent application 18675023 titled 'OLIGONUCLEOTIDES FOR TISSUE SPECIFIC GENE EXPRESSION MODULATION
Original Abstract Submitted
This disclosure relates to a therapeutic combination of drugs for the treatment or management of a neurodegenerative disease, the combination comprising: a first conjugate comprising an RNA silencing agent and a first targeting agent that targets the first conjugate to the central nervous system, and a second conjugate comprising an antagonist of the RNA silencing agent and a second targeting agent that targets the second conjugate to a off-target tissue.
