18660923. COMPOSITIONS AND METHODS FOR IMPROVED GENOME EDITING WITH NME2CAS9 AND NME2-SMUCAS9 VARIANTS (University of Massachusetts)
Contents
COMPOSITIONS AND METHODS FOR IMPROVED GENOME EDITING WITH NME2CAS9 AND NME2-SMUCAS9 VARIANTS
Organization Name
Inventor(s)
Erik Joseph Sontheimer of Auburndale MA (US)
Nathan Bamidele of Shrewsbury MA (US)
Zexiang Chen of Worcester MA (US)
COMPOSITIONS AND METHODS FOR IMPROVED GENOME EDITING WITH NME2CAS9 AND NME2-SMUCAS9 VARIANTS
This abstract first appeared for US patent application 18660923 titled 'COMPOSITIONS AND METHODS FOR IMPROVED GENOME EDITING WITH NME2CAS9 AND NME2-SMUCAS9 VARIANTS
Original Abstract Submitted
The present disclosure relates to (Nme) 2 Cas9 (Nme2Cas9) and Nme2Cas9 variants comprising one or more amino acid substitutions with increased genome editing activities (e.g., improve nuclease and base editing efficiencies).
