18744415. VECTORS, GENETICALLY MODIFIED CELLS, AND GENETICALLY MODIFIED NON-HUMAN ANIMALS COMPRISING THE SAME (Regeneron Pharmaceuticals, Inc.)
Contents
VECTORS, GENETICALLY MODIFIED CELLS, AND GENETICALLY MODIFIED NON-HUMAN ANIMALS COMPRISING THE SAME
Organization Name
Regeneron Pharmaceuticals, Inc.
Inventor(s)
Davor Frleta of Tarrytown NY (US)
John Mcwhirter of Tarrytown NY (US)
VECTORS, GENETICALLY MODIFIED CELLS, AND GENETICALLY MODIFIED NON-HUMAN ANIMALS COMPRISING THE SAME
This abstract first appeared for US patent application 18744415 titled 'VECTORS, GENETICALLY MODIFIED CELLS, AND GENETICALLY MODIFIED NON-HUMAN ANIMALS COMPRISING THE SAME
Original Abstract Submitted
Provided herein are genetically modified cells and genetically modified non-human animals (e.g., rodents such as rats and mice) comprising: (i) a homozygous null mutation in Rag2 gene; (ii) a homozygous null mutation in IL2rg gene; (iii) a homozygous null mutation in the non-human animal FMS-like tyrosine kinase 3 (Flt3) gene, and (iv) a Flt3 ligand (Flt31) gene that comprises a non-human animal portion and a human portion operably linked to a Flt31 promoter, and optionally expressing one or more human or humanized polypeptides. Methods and compositions of making and using such genetically modified cells and non-human animals are also provided.
