18289921. METHODS AND COMPOSITIONS FOR TREATING EPILEPSY (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE)
Contents
METHODS AND COMPOSITIONS FOR TREATING EPILEPSY
Organization Name
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventor(s)
Richard Porter of Binningen (CH)
Andrew Mercer of Rockville MD (US)
Olivier Danos of Rockville MD (US)
April R. Tepe of Laurel MD (US)
METHODS AND COMPOSITIONS FOR TREATING EPILEPSY
This abstract first appeared for US patent application 18289921 titled 'METHODS AND COMPOSITIONS FOR TREATING EPILEPSY
Original Abstract Submitted
Disclosed are methods and compositions relating to antisense therapy for treating epilepsy, such as a temporal lobe epilepsy, in a subject in need thereof by targeting Grik2 mRNA. In particular, the disclosure provides inhibitory RNA constructs capable of inhibiting expression of GluK2 protein and inhibiting epileptiform discharges in hyperexcitable neuronal circuits.
