18745495. POLYNUCLEOTIDE SYNTHESIS METHOD AND SYSTEM THEREFOR (Massachusetts Institute of Technology)
Contents
POLYNUCLEOTIDE SYNTHESIS METHOD AND SYSTEM THEREFOR
Organization Name
Massachusetts Institute of Technology
Inventor(s)
Nikhil Lal of Cambridge MA (US)
Eyal Perry of Cambridge MA (US)
Joseph Jacobson of Cambridge MA (US)
POLYNUCLEOTIDE SYNTHESIS METHOD AND SYSTEM THEREFOR
This abstract first appeared for US patent application 18745495 titled 'POLYNUCLEOTIDE SYNTHESIS METHOD AND SYSTEM THEREFOR
Original Abstract Submitted
A method of polynucleotide synthesis includes a series of enzymatic reactions for restriction, ligation, and amplification using a machine and system that provide efficient droplet-based reactions. The method enables hierarchical assembly with minimal handling in order to address challenges associated with traditional polynucleotide synthesis methods, such as high cost, limited throughput, long synthesis times, and limited ability to synthesize long sequences.
