The Regents of the University of California (20240376540). Compositions, Devices, Systems, and Methods for Using a Nanopore simplified abstract
Contents
Compositions, Devices, Systems, and Methods for Using a Nanopore
Organization Name
The Regents of the University of California
Inventor(s)
Mark A. Akeson of Santa Cruz CA (US)
Roger Jinteh Arrigo Chen of Saratoga CA (US)
Compositions, Devices, Systems, and Methods for Using a Nanopore - A simplified explanation of the abstract
This abstract first appeared for US patent application 20240376540 titled 'Compositions, Devices, Systems, and Methods for Using a Nanopore
The patent application describes devices and methods that can detect and control the interaction of an individual polymer in a mixture with another compound, such as an enzyme, in a nanopore. Additionally, these devices and methods can determine the nucleotide base sequence of a polynucleotide at frequencies greater than 50 Hz using feedback control or signals generated by the interactions between the polynucleotide and the nanopore. This innovation is particularly useful in molecular biology, structural biology, cell biology, molecular switches, molecular circuits, molecular computational devices, and their manufacturing.
- Detection and control of individual polymers in mixtures by other compounds in a nanopore
- Determination of nucleotide base sequences of polynucleotides at frequencies greater than 50 Hz
- Feedback control or signal-based sequencing of polynucleotides in nanopores
- Application in molecular biology, structural biology, cell biology, molecular switches, circuits, computational devices, and manufacturing
Potential Applications: - DNA sequencing - Drug development - Biomedical research - Genetic engineering - Nanotechnology
Problems Solved: - Accurate detection and control of polymer interactions - High-speed nucleotide sequencing - Enhanced precision in molecular biology research
Benefits: - Improved understanding of genetic structures - Faster and more efficient DNA sequencing - Facilitation of advanced biomedical research - Precision in genetic engineering applications
Commercial Applications: Title: Advanced DNA Sequencing Technology for Biomedical Research and Genetic Engineering This technology can be utilized in pharmaceutical companies, research institutions, genetic engineering firms, and biotechnology companies for DNA sequencing, drug development, and genetic research.
Questions about the technology: 1. How does this innovation improve the accuracy of DNA sequencing? 2. What are the potential implications of high-speed nucleotide sequencing in biomedical research and genetic engineering?
Original Abstract Submitted
devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. the devices and methods also determine (�>50 hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. the invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
