TSINGHUA UNIVERSITY (20240350709). MULTISTAGE SUSPENSION PRINTING METHOD FOR CONSTRUCTING COMPLEX HETEROGENEOUS TISSUE/ORGAN simplified abstract
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MULTISTAGE SUSPENSION PRINTING METHOD FOR CONSTRUCTING COMPLEX HETEROGENEOUS TISSUE/ORGAN
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MULTISTAGE SUSPENSION PRINTING METHOD FOR CONSTRUCTING COMPLEX HETEROGENEOUS TISSUE/ORGAN - A simplified explanation of the abstract
This abstract first appeared for US patent application 20240350709 titled 'MULTISTAGE SUSPENSION PRINTING METHOD FOR CONSTRUCTING COMPLEX HETEROGENEOUS TISSUE/ORGAN
Simplified Explanation:
The patent application describes a multistage embedded printing method for creating complex heterogeneous tissues/organs using a bioink made from cell-laden gel microspheres. This method involves printing the bioink in a suspension medium to build the tissue/organ structure and then printing substructures within it.
Key Features and Innovation:
- Preparation of bioink from cell-laden gel microspheres
- Printing in a suspension medium
- Multistage substructure printing
- Dissolving out the suspension medium after printing
- Gel microsphere ink with shear-thinning and self-healing properties
Potential Applications: This technology can be used in tissue engineering, regenerative medicine, drug testing, and personalized medicine.
Problems Solved: This method addresses the challenges of constructing complex tissues/organs with vascularized channels and heterogeneous cellular structures.
Benefits:
- Enables the creation of complex tissue/organ models
- Facilitates the development of personalized medical treatments
- Improves drug testing accuracy
Commercial Applications: The technology can be applied in pharmaceutical research, biotechnology companies, and medical device development.
Prior Art: Prior research in 3D bioprinting, tissue engineering, and regenerative medicine may provide insights into similar methods and technologies.
Frequently Updated Research: Stay updated on advancements in 3D bioprinting, tissue engineering, and regenerative medicine for potential improvements and new applications.
Questions about Multistage Embedded Printing Method for Constructing Complex Heterogeneous Tissue/Organ: 1. How does the multistage embedded printing method differ from traditional tissue engineering techniques? 2. What are the potential limitations of using gel microsphere ink in this printing method?
Original Abstract Submitted
a multistage embedded printing method for constructing a complex heterogeneous tissue/organ includes preparing a bioink formed from a cell-laden gel microsphere which is cross-linked, or is obtained by mixing a cell-laden gel microsphere which is cross-linked with a gel material which is not cross-linked. the method includes printing the bioink in a suspension medium to construct a specific construction of tissue/organ. the method includes further second stage or multistage substructure printing within the construction of the tissue/organ structure. the method includes, after printing, dissolving out the suspension medium after a whole cross-linking to obtain it. the multistage suspension 3d printing method uses a gel microsphere ink with both shear thinning and self-healing property, which can be printed in a suspension medium and then used as a suspension medium for a next stage structure printing, which is suitable for constructing a tissue/organ model with vascularized channel and a heterogeneous cellular structure.
