The Regents of the University of California (20240352517). Compositions, Devices, Systems, and Methods for Using a Nanopore simplified abstract

Compositions, Devices, Systems, and Methods for Using a Nanopore

Organization Name

The Regents of the University of California

Inventor(s)

Mark A. Akeson of Santa Cruz CA (US)

Roger Jinteh Arrigo Chen of Saratoga CA (US)

Compositions, Devices, Systems, and Methods for Using a Nanopore - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240352517 titled 'Compositions, Devices, Systems, and Methods for Using a Nanopore

• • Simplified Explanation:**

This patent application describes devices and methods that can detect and control the interaction of a polymer with another compound, such as an enzyme, in a nanopore. It also involves determining the nucleotide base sequence of a polynucleotide using signals generated by interactions with the nanopore.

• • Key Features and Innovation:**
• Devices and methods for detecting and controlling polymer interactions in a nanopore.
• Determination of nucleotide base sequences using feedback control or signals from nanopore interactions.

• • Potential Applications:**

This technology can be applied in molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices.

• • Problems Solved:**
• Enables precise control and detection of polymer interactions.
• Facilitates accurate determination of nucleotide base sequences.

• • Benefits:**
• Enhanced understanding of polymer interactions.
• Improved accuracy in determining nucleotide base sequences.

• • Commercial Applications:**

Potential commercial applications include the development of advanced molecular biology tools, diagnostic devices, and research instruments for the fields mentioned above.

• • Questions about the Technology:**

1. How does this technology improve the accuracy of determining nucleotide base sequences? 2. What are the specific applications of this technology in molecular biology research?

• • Frequently Updated Research:**

There may be ongoing research in the development of more efficient devices and methods for detecting and controlling polymer interactions in nanopores.

Original Abstract Submitted

devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. the devices and methods also determine (�>50 hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. the invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.