18629296. VACCINE ADJUVANTS, TRANSFECTION REAGENTS, AND METHODS OF USING THE SAME simplified abstract (WISCONSIN ALUMNI RESEARCH FOUNDATION)

VACCINE ADJUVANTS, TRANSFECTION REAGENTS, AND METHODS OF USING THE SAME

Organization Name

WISCONSIN ALUMNI RESEARCH FOUNDATION

Inventor(s)

Adel Talaat of Middleton WI (US)

Bubacarr Touray of Madison WI (US)

VACCINE ADJUVANTS, TRANSFECTION REAGENTS, AND METHODS OF USING THE SAME - A simplified explanation of the abstract

This abstract first appeared for US patent application 18629296 titled 'VACCINE ADJUVANTS, TRANSFECTION REAGENTS, AND METHODS OF USING THE SAME

• • Simplified Explanation:**

The patent application describes compositions of disaggregated spherical nanostructures containing Quil-A and DOTAP in specific ratios, along with methods of making and using them.

• • Key Features and Innovation:**

- Compositions of disaggregated spherical nanostructures with Quil-A and DOTAP - Ratios between 2:1 Quil-A: DOTAP to about 1:2 Quil-A: DOTAP - Methods of making and using these compositions

• • Potential Applications:**

- Vaccine adjuvants - Drug delivery systems - Biomedical research

• • Problems Solved:**

- Enhancing immune response - Improving drug delivery efficiency - Facilitating biomedical studies

• • Benefits:**

- Increased effectiveness of vaccines - Enhanced drug delivery to target cells - Advancement in biomedical research

• • Commercial Applications:**

Potential commercial applications include the development of novel vaccine adjuvants, drug delivery systems, and products for biomedical research.

• • Prior Art:**

Readers can explore prior research on Quil-A, DOTAP, and nanostructure compositions in the fields of vaccine development, drug delivery, and biotechnology.

• • Frequently Updated Research:**

Stay updated on the latest advancements in nanostructure technology, vaccine adjuvants, and drug delivery systems for potential improvements in healthcare and biomedicine.

• • Questions about Nanostructure Compositions:**

1. What are the specific benefits of using Quil-A and DOTAP in nanostructure compositions? 2. How do the ratios of Quil-A to DOTAP affect the properties of the disaggregated spherical nanostructures?

Original Abstract Submitted

Disclosed herein are compositions of disaggregated spherical nanostructures comprising Quil-A and dioleoyl 3 trimethylammonium propane (DOTAP) wherein the Quil-A and DOTAP are present at ratios between 2:1 Quil-A: DOTAP to about 1:2 Quil-A: DOTAP. Also provided are methods of making and using the same.