18279034. STRATEGIES TO DEVELOP GENOME EDITING SPHERICAL NUCLEIC ACIDS (SNAS) simplified abstract (NORTHWESTERN UNIVERSITY)
Contents
STRATEGIES TO DEVELOP GENOME EDITING SPHERICAL NUCLEIC ACIDS (SNAS)
Organization Name
Inventor(s)
Chad A. Mirkin of Wilmette IL (US)
Isaac Larkin of Chicago IL (US)
STRATEGIES TO DEVELOP GENOME EDITING SPHERICAL NUCLEIC ACIDS (SNAS) - A simplified explanation of the abstract
This abstract first appeared for US patent application 18279034 titled 'STRATEGIES TO DEVELOP GENOME EDITING SPHERICAL NUCLEIC ACIDS (SNAS)
The abstract describes the use of Spherical Nucleic Acids (SNAs) for delivering gene editing proteins into cells, allowing the proteins to remain enzymatically active and rapidly enter mammalian cells without the need for transfection reagents.
- SNAs are chemically tunable structures with biocompatibility that can enter cells quickly.
- The technology enables the delivery of gene editing proteins into cells, where they remain active.
- The gene editing proteins can rapidly enter mammalian cells without the use of transfection reagents.
- SNAs provide a promising platform for therapeutic delivery due to their unique properties.
- This innovation opens up new possibilities for gene editing and therapeutic applications.
Potential Applications: - Gene editing therapies - Drug delivery systems - Biomedical research
Problems Solved: - Overcoming the limitations of traditional gene editing delivery methods - Enhancing the efficiency of therapeutic delivery systems
Benefits: - Improved delivery of gene editing proteins - Enhanced therapeutic potential - Increased efficiency in biomedical research
Commercial Applications: Title: Innovative Gene Editing Delivery System with Spherical Nucleic Acids This technology has the potential to revolutionize gene editing therapies, drug delivery systems, and biomedical research. It could lead to the development of more effective treatments for various diseases and conditions.
Questions about Spherical Nucleic Acids: 1. How do SNAs compare to traditional gene editing delivery methods? SNAs offer a more efficient and rapid way to deliver gene editing proteins into cells compared to traditional methods like transfection.
2. What are the potential long-term implications of using SNAs for therapeutic delivery? Using SNAs for therapeutic delivery could lead to significant advancements in gene editing therapies and drug delivery systems, potentially revolutionizing the field of biomedicine.
Original Abstract Submitted
Spherical nucleic acids (SNAs) are an attractive platform for therapeutic delivery due to their chemically tunable structures, biocompatibility, and ability to rapidly enter cells without transfection reagents. The present disclosure provides SNAs and strategies for delivering gene editing proteins into cells. The delivered gene editing proteins remain enzymatically active and rapidly enter mammalian cells.
