18575597. ENHANCED EXPRESSION OF AN AROMATIC AMINO ACID DECARBOXYLASE (AADC) IN THE SUBSTANTIA NIGRA FOR THE TREATMENT OF PARKINSON'S DISEASE simplified abstract (NORTHWESTERN UNIVERSITY)
ENHANCED EXPRESSION OF AN AROMATIC AMINO ACID DECARBOXYLASE (AADC) IN THE SUBSTANTIA NIGRA FOR THE TREATMENT OF PARKINSON'S DISEASE
Organization Name
Inventor(s)
Dalton James Surmeier, Jr. of Evanston IL (US)
Patricia Gonzalez Rodriguez of Evanston IL (US)
Michael J. Kaplitt of Ithaca NY (US)
ENHANCED EXPRESSION OF AN AROMATIC AMINO ACID DECARBOXYLASE (AADC) IN THE SUBSTANTIA NIGRA FOR THE TREATMENT OF PARKINSON'S DISEASE - A simplified explanation of the abstract
This abstract first appeared for US patent application 18575597 titled 'ENHANCED EXPRESSION OF AN AROMATIC AMINO ACID DECARBOXYLASE (AADC) IN THE SUBSTANTIA NIGRA FOR THE TREATMENT OF PARKINSON'S DISEASE
- Simplified Explanation:**
Methods and compositions for treating Parkinson's disease by enhancing the expression of AADC in the substantia nigra to extend the beneficial effects of levodopa.
- Key Features and Innovation:**
- Treatment of Parkinson's disease by enhancing AADC expression in the substantia nigra - Extension of the beneficial effects of levodopa in PD patients
- Potential Applications:**
- Treatment of Parkinson's disease - Alleviation of symptoms associated with PD
- Problems Solved:**
- Limited effectiveness of levodopa in treating Parkinson's disease - Need for alternative or complementary treatments for PD
- Benefits:**
- Extended beneficial effects of levodopa in PD patients - Improved management of symptoms associated with Parkinson's disease
- Commercial Applications:**
- Potential applications in pharmaceutical industry for developing new treatments for Parkinson's disease - Market implications in the healthcare sector for improved management of PD
- Questions about Parkinson's Disease:**
1. How does enhancing AADC expression in the substantia nigra improve the treatment of Parkinson's disease? 2. What are the potential long-term effects of extending the beneficial effects of levodopa in PD patients?
Original Abstract Submitted
Provided herein are methods and compositions for treating Parkinson's disease (PD), or alleviating symptoms thereof, by the enhancing expression of aromatic acid decarboxylase (AADC) in the substantia nigra. In particular, the beneficial effects of levodopa to subjects suffering from PD are extended by enhancing the expression of AADC in the substantia nigra of the subject.
