18656957. HIGH CONCENTRATION ANTIBODY-CONTAINING LIQUID FORMULATION simplified abstract (Hoffmann-La Roche Inc.)
Contents
HIGH CONCENTRATION ANTIBODY-CONTAINING LIQUID FORMULATION
Organization Name
Inventor(s)
Toshiyuki Morichika of Tokyo (JP)
Oliver Boris Stauch of Freiburg (DE)
HIGH CONCENTRATION ANTIBODY-CONTAINING LIQUID FORMULATION - A simplified explanation of the abstract
This abstract first appeared for US patent application 18656957 titled 'HIGH CONCENTRATION ANTIBODY-CONTAINING LIQUID FORMULATION
The abstract describes a patent application for a stable antibody-containing liquid formulation suitable for subcutaneous administration, preventing dimerization or deamidation during long-term storage by using arginine and histidine buffer.
- Simplified Explanation:
- Patent application for stable antibody formulation with arginine and histidine buffer to prevent dimerization or deamidation during storage.
- Key Features and Innovation:
- Contains arginine and histidine buffer to inhibit deamidation or dimerization. - Suitable for subcutaneous administration. - Prevents issues during long-term storage.
- Potential Applications:
- Treatment of conditions related to IL-6 receptor. - Pharmaceutical industry for antibody formulations.
- Problems Solved:
- Prevents dimerization or deamidation of antibodies during storage. - Ensures stability of the formulation for subcutaneous administration.
- Benefits:
- Increased shelf-life of antibody formulations. - Improved efficacy of anti-IL-6 receptor treatment. - Enhanced patient experience with subcutaneous administration.
- Commercial Applications:
- Title: "Stable Antibody Formulation for Subcutaneous Administration" - Potential use in pharmaceutical companies for developing antibody-based treatments. - Market implications in the field of biologics and immunotherapy.
- Questions about the Technology:
1. How does the use of arginine and histidine buffer prevent dimerization or deamidation of antibodies? - The arginine and histidine buffer helps maintain the stability of the antibodies by inhibiting chemical reactions that lead to dimerization or deamidation.
2. What are the advantages of subcutaneous administration of antibody formulations? - Subcutaneous administration offers convenience, reduced risk of infection, and potentially improved patient compliance compared to other routes of administration.
Original Abstract Submitted
The problem to be solved is to provide a humanized anti-IL-6 receptor antibody MRA-containing formulation which is suitable for subcutaneous administration, wherein dimerization or deamidation is prevented during long-term storage. The present application is directed to a stable antibody-containing liquid formulation characterized by containing arginine and histidine buffer. A method of inhibiting deamidation or dimerization of such an antibody in a concentrated liquid formulation includes histidine buffer in the liquid formulation.
