18600605. BIOMOLECULE IMMOBILIZATION METHOD simplified abstract (ILLUMINA, INC.)

BIOMOLECULE IMMOBILIZATION METHOD

Organization Name

ILLUMINA, INC.

Inventor(s)

Samantha Kelly Brittelle of San Diego CA (US)

Tyler J. Dill of San Diego CA (US)

Michelle Kate Fu of San Diego CA (US)

Ryan David Mccurdy of San Diego CA (US)

Michael L. Neville of San Diego CA (US)

Sean M. Ramirez of San Diego CA (US)

Stuart A. Sardo of San Diego CA (US)

BIOMOLECULE IMMOBILIZATION METHOD - A simplified explanation of the abstract

This abstract first appeared for US patent application 18600605 titled 'BIOMOLECULE IMMOBILIZATION METHOD

The abstract describes a method where a grafting solution is applied to a patterned substrate using a liquid-phase thin-film deposition technique. The patterned substrate contains a lane or a plurality of depressions with a polymer functionalized with a first click reaction moiety.

• The grafting solution includes a solvent, a polymer matrix material, and primers with a second click reaction moiety.
• The applied grafting solution is dried to form a solid polymer matrix where the primers attach to the polymer via click reaction moieties in the lane or depressions.

Potential Applications: - This technology can be used in the field of microelectronics for creating precise patterns on substrates. - It can also be applied in the biomedical industry for controlled drug delivery systems.

Problems Solved: - Provides a method for precise and controlled deposition of polymers on patterned substrates. - Enables functionalization of polymers with specific reaction moieties for targeted applications.

Benefits: - Allows for tailored surface modifications on substrates. - Enhances the adhesion and compatibility of polymers with the substrate.

Commercial Applications: "Patterned Substrate Grafting Solution for Microelectronics and Biomedical Applications"

Frequently Updated Research: - Stay updated on advancements in liquid-phase thin-film deposition techniques for patterned substrates.

Questions about Patterned Substrate Grafting Solution: 1. How does this technology improve the precision of polymer deposition on patterned substrates? 2. What are the potential challenges in scaling up this method for industrial applications?

Original Abstract Submitted

In an example method, a grafting solution is applied to a patterned substrate using a liquid-phase thin-film deposition technique. The patterned substrate includes a lane surrounded by, or a plurality of depressions separated by interstitial regions; and a polymer in the lane or in each of the plurality of depressions. The polymer is functionalized with a first click reaction moiety. The grafting solution includes a solvent; a polymer matrix material dissolved in the solvent; and primers of a primer set dissolved in the solvent, each of the primers being terminated with a second click reaction moiety. The applied grafting solution is dried. During drying, a solid polymer matrix is formed and at least some of the primers attach to the polymer i) via the first and second click reaction moieties and ii) in at least a portion of the lane or in at least some of the plurality of depressions.