18422188. MASS SPECTROMETRY-BASED CHARACTERIZATION OF ANTIBODIES CO-EXPRESSED IN VIVO simplified abstract (Regeneron Pharmaceuticals, Inc.)
Contents
MASS SPECTROMETRY-BASED CHARACTERIZATION OF ANTIBODIES CO-EXPRESSED IN VIVO
Organization Name
Regeneron Pharmaceuticals, Inc.
Inventor(s)
Yuetian Yan of Chappaqua NY (US)
Shunhai Wang of Scarsdale NY (US)
MASS SPECTROMETRY-BASED CHARACTERIZATION OF ANTIBODIES CO-EXPRESSED IN VIVO - A simplified explanation of the abstract
This abstract first appeared for US patent application 18422188 titled 'MASS SPECTROMETRY-BASED CHARACTERIZATION OF ANTIBODIES CO-EXPRESSED IN VIVO
The present invention involves methods for characterizing a protein of interest using native immunoprecipitation and native strong cation exchange chromatography-mass spectrometry to identify and quantify pairing products of antibodies co-expressed in vivo.
- Utilizes native immunoprecipitation and native strong cation exchange chromatography-mass spectrometry.
- Identifies and quantifies pairing products of antibodies co-expressed in vivo.
- Provides a method for characterizing a protein of interest.
- Offers a new approach to studying protein interactions.
- Enables researchers to better understand antibody pairing in biological systems.
Potential Applications: This technology can be used in the fields of biotechnology, pharmaceuticals, and medical research for studying protein interactions, antibody pairing, and protein characterization.
Problems Solved: This technology addresses the challenges of accurately identifying and quantifying pairing products of antibodies co-expressed in vivo, providing a more comprehensive understanding of protein interactions.
Benefits: - Improved accuracy in identifying and quantifying antibody pairing products - Enhanced understanding of protein interactions - Potential for developing new therapeutic antibodies
Commercial Applications: Title: Protein Characterization Technology for Biotechnology and Pharmaceutical Industries This technology can be utilized by biotechnology and pharmaceutical companies for drug development, protein engineering, and biomarker discovery, leading to advancements in healthcare and biotechnology products.
Prior Art: Researchers can explore prior studies on protein characterization, antibody pairing, and protein interaction analysis to build upon existing knowledge in this field.
Frequently Updated Research: Stay updated on the latest advancements in protein characterization, antibody pairing, and protein interaction analysis to incorporate cutting-edge techniques and methodologies into research projects.
Questions about Protein Characterization Technology: 1. How does this technology improve the understanding of protein interactions? 2. What are the potential applications of native immunoprecipitation and native strong cation exchange chromatography-mass spectrometry in protein research?
Original Abstract Submitted
The present inventions generally pertains to methods of characterizing of a protein of interest. In particular, the present inventions pertains to the use of native immunoprecipitation and native strong cation exchange chromatography-mass spectrometry for identifying and quantifying the pairing products of two or more antibodies co-expressed in vivo.
