17415589. Compositions and Methods for Enhancing Body Weight and Lean Muscle Mass Using Antagonists Against Leptin Receptor, GDF8 and Activin A simplified abstract (Regeneron Pharmaceuticals, Inc.)
Compositions and Methods for Enhancing Body Weight and Lean Muscle Mass Using Antagonists Against Leptin Receptor, GDF8 and Activin A
Organization Name
Regeneron Pharmaceuticals, Inc.
Inventor(s)
Judith Altarejos of Armonk NY (US)
Jesper Gromada of Concord MA (US)
Compositions and Methods for Enhancing Body Weight and Lean Muscle Mass Using Antagonists Against Leptin Receptor, GDF8 and Activin A - A simplified explanation of the abstract
This abstract first appeared for US patent application 17415589 titled 'Compositions and Methods for Enhancing Body Weight and Lean Muscle Mass Using Antagonists Against Leptin Receptor, GDF8 and Activin A
Simplified Explanation: The patent application discusses combinations of antagonists of leptin receptor, GDF8, and Activin A for increasing lean body mass and treating conditions like malnutrition and cachexia.
Key Features and Innovation:
- Combinations of antagonists of leptin receptor, GDF8, and Activin A
- Increase in lean body mass at the expense of fat mass
- Treatment of malnutrition, cachexia, and weight loss conditions
Potential Applications: The technology can be used in the medical field for treating malnutrition, cachexia, and other conditions related to insufficient nutrition and weight loss.
Problems Solved: This technology addresses the issues of insufficient nutrition, weight loss, and muscle wasting in conditions like cachexia.
Benefits:
- Increase in lean body mass
- Treatment of malnutrition and cachexia
- Improvement in overall health and well-being
Commercial Applications: The technology has potential commercial applications in the pharmaceutical industry for developing treatments for malnutrition and cachexia, catering to a market of individuals suffering from these conditions.
Prior Art: Readers can explore prior research on leptin receptor antagonists, GDF8, and Activin A in the context of treating malnutrition and cachexia.
Frequently Updated Research: Stay updated on the latest research on leptin receptor antagonists, GDF8, and Activin A for potential advancements in treating malnutrition and cachexia.
Questions about Combinations of Antagonists of Leptin Receptor, GDF8, and Activin A: 1. What are the potential side effects of using these combinations in treating malnutrition and cachexia? 2. How do these antagonists specifically target lean body mass increase in patients with weight loss conditions?
Original Abstract Submitted
The present invention provides combinations including antagonists of leptin receptor, GDF8 and Activin A and methods of use thereof. Such compositions are effective for example for causing an increase in lean body mass, at least in part, at the expense of fat mass. Methods for treating malnutrition, cachexia and other conditions characterized by insufficient nutrition and weight loss are also provided.
