Taiwan semiconductor manufacturing company, ltd. (20240240131). INTEGRATED CELL MONITORING APPARATUS simplified abstract

INTEGRATED CELL MONITORING APPARATUS

Organization Name

taiwan semiconductor manufacturing company, ltd.

Inventor(s)

Yi-Hsing Hsiao of Hsinchu City (TW)

Jui-Cheng Huang of Hsinchu City (TW)

INTEGRATED CELL MONITORING APPARATUS - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240240131 titled 'INTEGRATED CELL MONITORING APPARATUS

The abstract describes a cell monitoring apparatus consisting of a sensing chip and a channel module. The sensing chip includes a channel region, source and drain regions, and a sensing film. The channel region is made of a first semiconductor material, while the source and drain regions, made of a second semiconductor material, are located on opposite sides of the channel region. The sensing film is placed on the channel region's sensing surface. The channel module is positioned on the sensing chip's sensing surface, creating a microfluidic channel between the two surfaces. This channel contains a culture chamber and a micro-well, with the culture chamber curving into the channel module's surface and covering the channel region, while the micro-well is concave into the culture chamber's side and faces the sensing film directly.

• The apparatus includes a sensing chip with a channel region, source and drain regions, and a sensing film.
• The channel module is placed on the sensing chip, forming a microfluidic channel with a culture chamber and a micro-well.
• The culture chamber covers the channel region and is concave into the channel module's surface.
• The micro-well is concave into the culture chamber's side and faces the sensing film directly.
• This design allows for efficient cell monitoring and analysis in a controlled microfluidic environment.

Potential Applications: - Cell culture monitoring - Drug screening - Biomedical research

Problems Solved: - Precise and controlled cell monitoring - Enhanced analysis of cellular behavior - Improved drug testing accuracy

Benefits: - Real-time monitoring of cell responses - High sensitivity and accuracy in analysis - Facilitates drug discovery and development processes

Commercial Applications: Title: Advanced Cell Monitoring Apparatus for Biomedical Research and Drug Development This technology can be utilized in pharmaceutical companies, research institutions, and biotechnology firms for cell-based assays, drug screening, and personalized medicine research.

Prior Art: Further research can be conducted in the field of microfluidic devices for cell analysis and monitoring to explore similar innovations and advancements.

Frequently Updated Research: Stay updated on the latest developments in microfluidics, semiconductor materials, and cell monitoring technologies to enhance the efficiency and accuracy of cell analysis processes.

Questions about Cell Monitoring Apparatus: 1. How does the design of the micro-well contribute to the accuracy of cell monitoring? The micro-well's direct facing of the sensing film allows for precise detection and analysis of cellular responses. 2. What are the potential implications of this technology in personalized medicine research? This technology can revolutionize drug development processes by enabling tailored treatments based on individual cell responses.

Original Abstract Submitted

cell monitoring apparatus includes sensing chip and channel module. sensing chip includes channel region, source and drain regions, and sensing film. the channel region includes first semiconductor material. the source and drain regions are disposed at opposite sides of the channel region, and include a second semiconductor material. sensing film is disposed on the channel region at a sensing surface of the sensing chip. channel module is disposed on the sensing surface of sensing chip. a microfluidic channel is formed between the sensing surface of the sensing chip and a proximal surface of the channel module. the microfluidic channel includes a culture chamber and a micro-well. the culture chamber is concave into the proximal surface of the channel module, and overlies the channel region. the micro-well is concave into a side of the culture chamber, and directly faces the sensing film.