View source for US Patent Application 18200837. Mechanical Pulsed Ultrasound Therapy for Modulating Neural Tissue Microenvironments simplified abstract

=Mechanical Pulsed Ultrasound Therapy for Modulating Neural Tissue Microenvironments=


==Organization Name==

[[:Category:Wisconsin Alumni Research Foundation|Wisconsin Alumni Research Foundation]]


[[Category:Wisconsin Alumni Research Foundation]]

==Inventor(s)==

[[:Category:John-Paul Yu of Madison WI (US)|John-Paul Yu of Madison WI (US)]][[Category:John-Paul Yu of Madison WI (US)]]

==Mechanical Pulsed Ultrasound Therapy for Modulating Neural Tissue Microenvironments - A simplified explanation of the abstract==


This abstract first appeared for US patent application 18200837 titled 'Mechanical Pulsed Ultrasound Therapy for Modulating Neural Tissue Microenvironments

==Simplified Explanation==

- The patent application describes a method using short ultrasound pulses to target brain tissue.
- The ultrasound pulses are delivered at intermediate intensity to avoid generating acoustic cavitation and damaging cells.
- The invention focuses on utilizing the mechanical effects of high-intensity pressure fields without cavitation.
- The goal is to apply a negative pressure to the brain tissue, degrade the perineuronal nets, and open the blood-brain barrier.
- The innovation aims to improve the delivery of treatments or substances to the brain by safely manipulating brain tissue using ultrasound technology.


==Original Abstract Submitted==

Short ultrasound pulses or bursts, delivered at intermediate intensity to the target brain tissue transmits acoustic radiation forces into the targeted brain tissue without generating acoustic cavitation and without cellular fractionization. Thus, the present invention exploits the mechanical effects of high-intensity pressure fields only, without cavitation, by optimizing the interaction between acoustic pulses and radiation forces to apply a negative pressure to the brain tissue and degrading the perineuronal nets in the brain tissue and opening the blood-brain barrier.



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