View source for US Patent Application 18066151. ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF simplified abstract

=ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF=


==Organization Name==

[[The Regents of the University of California]]


==Inventor(s)==

[[David V. Schaffer of Danville CA (US)]]


[[John G. Flannery of Berkeley CA (US)]]


[[William A. Beltran of Philadelphia PA (US)]]


[[Leah C. Byrne of San Francisco CA (US)]]


[[Meike Visel of El Cerrito CA (US)]]


==ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF - A simplified explanation of the abstract==


*This abstract for appeared for US patent application  number 18066151 Titled 'ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF'

==Simplified Explanation==

This abstract describes a new discovery involving a type of virus called adeno-associated virus (AAV). The researchers have modified the capsid protein of the AAV virions, which are the outer shells of the virus. These modified AAV virions are found to be more effective in infecting retinal cells compared to the natural AAV. The researchers also provide methods for using these modified AAV virions to deliver a gene product to retinal cells in order to treat eye diseases.


==Original Abstract Submitted==

The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.