View source for 20250188476. Compounds Meth (Ionis Pharmaceuticals, .)

= COMPOUNDS AND METHODS FOR REDUCING IFNAR1 EXPRESSION =

'''Abstract''':
provided are oligomeric agents, oligomeric compounds, methods, and pharmaceutical compositions for reducing the amount or activity of ifnar1 rna in a cell or an animal, and in certain instances, reducing the amount of ifnar1 protein in a cell or animal. such oligomeric agents, oligomeric compounds, methods, and pharmaceutical compositions are useful to treat diseases and conditions associated with neuroinflammation, including aicardi-goutieres syndrome, stroke, neuropsychiatric systemic lupus erythematosus, neuroinflammation following traumatic brain injury, neuro-autoimmune disorders, alzheimer's disease, post-operative delirium and cognitive decline, cranial radiation-induced cognitive decline, viral infection-induced cognitive decline, neuromyelitis optica, and ataxia telangiectasia.

'''Inventor(s)''': [[:Category:Fredrik Carl Kamme of Encinitas CA US|Fredrik Carl Kamme]], [[:Category:Huynh-Hoa Bui of San Diego CA US|Huynh-Hoa Bui]], [[:Category:Susan M. Freier of San Diego CA US|Susan M. Freier]], [[:Category:Swagatam Mukhopadhyay of Oceanside CA US|Swagatam Mukhopadhyay]]

'''CPC Classification''': [[:Category:CPC_C12N15/1138|C12N15/1138]] ({against receptors or cell surface proteins})


[[Category:Patent Applications]]
[[Category:Ionis Pharmaceuticals, Inc.]]
[[Category:CPC_C12N15/1138]]
[[Category:Fredrik Carl Kamme of Encinitas CA US]]
[[Category:Huynh-Hoa Bui of San Diego CA US]]
[[Category:Susan M. Freier of San Diego CA US]]
[[Category:Swagatam Mukhopadhyay of Oceanside CA US]]

[https://wikipatents.org/index.php?search=20250188476+rejection&title=Special%3ASearch&wprov=acrw1_-1 Search for rejections for patent application number 20250188476]


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