View source for 20240024363. TREATMENT OF LIMB ISCHEMIA BY BONE MARROW STEM CELLS AND MODIFICATION OF DISEASED MICROENVIRONMENT simplified abstract (CREATIVE MEDICAL TECHNOLOGIES, INC.)

=TREATMENT OF LIMB ISCHEMIA BY BONE MARROW STEM CELLS AND MODIFICATION OF DISEASED MICROENVIRONMENT=


==Organization Name==

[[:Category:CREATIVE MEDICAL TECHNOLOGIES, INC.|CREATIVE MEDICAL TECHNOLOGIES, INC.]]


[[Category:CREATIVE MEDICAL TECHNOLOGIES, INC.]]

==Inventor(s)==

[[:Category:Thomas Ichim of San Diego CA (US)|Thomas Ichim of San Diego CA (US)]][[Category:Thomas Ichim of San Diego CA (US)]]

[[:Category:Amit Patel of Salt Lake City UT (US)|Amit Patel of Salt Lake City UT (US)]][[Category:Amit Patel of Salt Lake City UT (US)]]

[[:Category:Courtney Bartlett of Niceville FL (US)|Courtney Bartlett of Niceville FL (US)]][[Category:Courtney Bartlett of Niceville FL (US)]]

==TREATMENT OF LIMB ISCHEMIA BY BONE MARROW STEM CELLS AND MODIFICATION OF DISEASED MICROENVIRONMENT - A simplified explanation of the abstract==


This abstract first appeared for US patent application 20240024363 titled 'TREATMENT OF LIMB ISCHEMIA BY BONE MARROW STEM CELLS AND MODIFICATION OF DISEASED MICROENVIRONMENT

==Simplified Explanation==

The patent application describes methods and compositions for treating limb ischemia, specifically Beurger's disease. The treatment involves the use of bone marrow stem cells, which are administered before, during, and after the administration of agents that modify the microenvironment of the ischemic limb. In one embodiment, the agents used are antioxidants that can diffuse across ischemic areas and preserve the regenerative activity of the stem cells. In another embodiment, hormonal modifications are used to overcome deficiencies associated with ischemia predisposing pathologies.

* Methods and compositions for treating limb ischemia, specifically Beurger's disease.
* Use of bone marrow stem cells in the treatment.
* Administration of agents that modify the microenvironment of the ischemic limb.
* Antioxidants used as the modifying agents to preserve regenerative activity of stem cells.
* Hormonal modifications used to overcome deficiencies associated with ischemia predisposing pathologies.

== Potential Applications ==
* Treatment of limb ischemia, specifically Beurger's disease.
* Regeneration and repair of ischemic tissues.
* Improvement of blood flow and circulation in the affected limb.

== Problems Solved ==
* Lack of effective treatments for limb ischemia, particularly Beurger's disease.
* Inability to preserve regenerative activity of stem cells in ischemic areas.
* Deficiencies associated with ischemia predisposing pathologies.

== Benefits ==
* Improved outcomes for patients with limb ischemia.
* Enhanced regeneration and repair of ischemic tissues.
* Preservation of regenerative activity of stem cells.
* Overcoming deficiencies associated with ischemia predisposing pathologies.


==Original Abstract Submitted==

methods and compositions are provided to treat limb ischemia such as beurger's disease through the use of bone marrow stem cells that are administered prior to, concurrently with, and subsequently to administration of agents that modify the microenvironment of the ischemic limb(s). in one embodiment, said agents are antioxidants, more specifically antioxidants capable of diffusing across ischemic areas and preserving regenerative activity of administered stem cells. in another embodiment, the invention provides hormonal modifications to overcome deficiencies associated with ischemia predisposing pathologies.



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