View source for 20240024241. Powder Blend Processability Improvements Through Minimal Amounts Of Synergistically Selected Surface Coating Agents simplified abstract (NEW JERSEY INSTITUTE OF TECHNOLOGY)

=Powder Blend Processability Improvements Through Minimal Amounts Of Synergistically Selected Surface Coating Agents=


==Organization Name==

[[:Category:NEW JERSEY INSTITUTE OF TECHNOLOGY|NEW JERSEY INSTITUTE OF TECHNOLOGY]]


[[Category:NEW JERSEY INSTITUTE OF TECHNOLOGY]]

==Inventor(s)==

[[:Category:Rajesh N. Dave of Princeton NJ (US)|Rajesh N. Dave of Princeton NJ (US)]][[Category:Rajesh N. Dave of Princeton NJ (US)]]

[[:Category:Sangah Kim of Newark NJ (US)|Sangah Kim of Newark NJ (US)]][[Category:Sangah Kim of Newark NJ (US)]]

[[:Category:Zhixing Lin of Newark NJ (US)|Zhixing Lin of Newark NJ (US)]][[Category:Zhixing Lin of Newark NJ (US)]]

==Powder Blend Processability Improvements Through Minimal Amounts Of Synergistically Selected Surface Coating Agents - A simplified explanation of the abstract==


This abstract first appeared for US patent application 20240024241 titled 'Powder Blend Processability Improvements Through Minimal Amounts Of Synergistically Selected Surface Coating Agents

==Simplified Explanation==

The abstract of the patent application describes a method of improving the flowability and physical properties of powdered/nanoparticle APIs (Active Pharmaceutical Ingredients) by loading them with high (greater than 30%) and/or low (less than 10%) amounts of other powdered ingredients. The properties that are improved include blend flowability and uniformity, bulk packing density, compactability, tensile strength, and dissolution. The blending process involves solventless dry mechanical coating of at least one minority API component, which is the API component with the least weight per volume surface, with nano-sized powders in lesser amounts by weight percentage of the blend (preferably less than 10% dry coated of the minority API). Minority excipients may also be dry coated in lesser amounts, and both minority excipient and minority API can be dry coated. This dry coating method is more efficient and cost-effective compared to traditional dry granulation and wet granulation techniques, and it produces higher quality tablets with unexpectedly improved properties for low flowability solid powdered ingredients.

* The patent application describes a method of improving the flowability and physical properties of powdered/nanoparticle APIs.
* The method involves loading the APIs with high and/or low amounts of other powdered ingredients.
* The improved properties include blend flowability and uniformity, bulk packing density, compactability, tensile strength, and dissolution.
* The blending process is done through solventless dry mechanical coating of at least one minority API component.
* The minority API component is defined as the API component with the least weight per volume surface.
* Nano-sized powders are used to coat the minority API component in lesser amounts by weight percentage of the blend (preferably less than 10% dry coated of the minority API).
* Minority excipients may also be dry coated in lesser amounts.
* Both minority excipient and minority API can be dry coated.
* Dry coating is more efficient and cost-effective compared to traditional dry granulation and wet granulation techniques.
* The method produces higher quality tablets with unexpectedly improved properties for low flowability solid powdered ingredients.

== Potential Applications ==
* Pharmaceutical industry: This technology can be applied in the production of tablets and other solid dosage forms in the pharmaceutical industry.
* Drug manufacturing: The method can be used to improve the properties of APIs, ensuring better drug delivery and efficacy.
* Formulation development: Pharmaceutical companies can utilize this technology to enhance the flowability and physical properties of their drug formulations.

== Problems Solved ==
* Poor flowability of solid powdered ingredients: The technology addresses the problem of low flowability in solid powdered ingredients, which can hinder the manufacturing process and affect the quality of the final product.
* Inefficient granulation techniques: The dry coating method provides a more efficient and cost-effective alternative to traditional dry granulation and wet granulation techniques, reducing manufacturing steps and costs.

== Benefits ==
* Improved flowability and physical properties: The technology improves the flowability, blend uniformity, bulk packing density, compactability, tensile strength, and dissolution of powdered/nanoparticle APIs.
* Cost savings: By eliminating the need for traditional granulation techniques, the method saves manufacturing steps and costs.
* Higher quality tablets: The dry coating method produces tablets with higher quality and improved properties compared to conventional techniques.
* Enhanced drug delivery: The improved properties of the APIs ensure better drug delivery and efficacy.


==Original Abstract Submitted==

high(greater than 30%) and/or low(less than 10%) loaded multiple api powdered/nanoparticle were tabulated with increased flowability and physical properties. properties include blend flowability and uniformity, bulk packing density, compactability, tensile strength, and dissolution. blending is done through solventless dry mechanical coating of at least one minority api component defined as the api component with the least weight per volume surface coated with nano-sized powders in lesser amounts by wt % of the blend, and preferably less than 10% dry coated of the minority api. an excipient may be dry coated in the lesser amount wherein the excipient is a minority component. both minority excipient and minority api may be dry coated. using dry coating instead of dry granulation and/or wet granulation techniques in producing tablets saves manufacturing steps, costs, and produces higher quality tablets with surprisingly higher properties than expected for low flowability solid powdered ingredients.



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