View source for 18628116. METHODS FOR THE PURIFICATION OF L-GLUFOSINATE simplified abstract (BASF SE)

=METHODS FOR THE PURIFICATION OF L-GLUFOSINATE=


==Organization Name==

[[:Category:BASF SE|BASF SE]]


[[Category:BASF SE]]

==Inventor(s)==

[[:Category:Stephen Craig Fields of Baltimore MD (US)|Stephen Craig Fields of Baltimore MD (US)]][[Category:Stephen Craig Fields of Baltimore MD (US)]]

[[:Category:Matthew Richard Oberholzer of Wilmington DE (US)|Matthew Richard Oberholzer of Wilmington DE (US)]][[Category:Matthew Richard Oberholzer of Wilmington DE (US)]]

[[:Category:Brian Michael Green of Lutherville MD (US)|Brian Michael Green of Lutherville MD (US)]][[Category:Brian Michael Green of Lutherville MD (US)]]

[[:Category:Samir Kulkarni of East Lyme CT (US)|Samir Kulkarni of East Lyme CT (US)]][[Category:Samir Kulkarni of East Lyme CT (US)]]

[[:Category:Jennifer Nelson of Kokomo IN (US)|Jennifer Nelson of Kokomo IN (US)]][[Category:Jennifer Nelson of Kokomo IN (US)]]

[[:Category:Patricia Andres of West Lafayette IN (US)|Patricia Andres of West Lafayette IN (US)]][[Category:Patricia Andres of West Lafayette IN (US)]]

==METHODS FOR THE PURIFICATION OF L-GLUFOSINATE - A simplified explanation of the abstract==


This abstract first appeared for US patent application 18628116 titled 'METHODS FOR THE PURIFICATION OF L-GLUFOSINATE

Abstract: Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method involves converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate to obtain substantially purified L-glufosinate. The composition is subjected to an elevated temperature to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate. The purified L-glufosinate is present in the final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate.

Key Features and Innovation:
* Isolation of L-glufosinate from a composition containing L-glufosinate and glutamate.
* Conversion of glutamate to pyroglutamate for purification of L-glufosinate.
* Use of elevated temperature for conversion and isolation process.
* Purified L-glufosinate present at a concentration of 90% or greater in the final composition.
* Potential enzymatic conversion of glutamate to pyroglutamate.

Potential Applications:
The technology can be applied in the pharmaceutical industry for the production of purified L-glufosinate for various medical applications. It can also be used in agriculture for the development of herbicides.

Problems Solved:
The technology addresses the challenge of isolating and purifying L-glufosinate from compositions containing glutamate, ensuring a high concentration of the desired compound in the final product.

Benefits:
* High purity of L-glufosinate in the final composition.
* Efficient conversion and isolation process.
* Versatile applications in pharmaceuticals and agriculture.

Commercial Applications:
This technology has significant commercial potential in pharmaceutical manufacturing for producing high-quality L-glufosinate-based products. It can also be utilized in the agricultural sector for the development of effective herbicides.

Prior Art:
Readers interested in exploring prior art related to this technology can start by researching methods for isolating and purifying amino acids from complex compositions.

Frequently Updated Research:
Researchers are continually exploring new methods and techniques for enhancing the efficiency and yield of isolating L-glufosinate from compositions containing glutamate.

Questions about L-glufosinate:
1. What are the potential environmental implications of using L-glufosinate-based herbicides?
2. How does the conversion of glutamate to pyroglutamate contribute to the purification process of L-glufosinate?


==Original Abstract Submitted==

Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.



[[Category:C07F9/535]]
[[Category:C07F9/30]]
[[Category:CPC_C07F9/535]]