View source for 18597797. ADAM6 MICE simplified abstract (Regeneron Pharmaceuticals, Inc.)

=ADAM6 MICE=


==Organization Name==

[[:Category:Regeneron Pharmaceuticals, Inc.|Regeneron Pharmaceuticals, Inc.]]


[[Category:Regeneron Pharmaceuticals, Inc.]]

==Inventor(s)==

[[:Category:Lynn Macdonald of Harrison NY (US)|Lynn Macdonald of Harrison NY (US)]][[Category:Lynn Macdonald of Harrison NY (US)]]

[[:Category:Sean Stevens of Del Mar CA (US)|Sean Stevens of Del Mar CA (US)]][[Category:Sean Stevens of Del Mar CA (US)]]

[[:Category:Andrew J. Murphy of Croton-on-Hudson NY (US)|Andrew J. Murphy of Croton-on-Hudson NY (US)]][[Category:Andrew J. Murphy of Croton-on-Hudson NY (US)]]

[[:Category:Margaret Karow of Santa Rosa Valley CA (US)|Margaret Karow of Santa Rosa Valley CA (US)]][[Category:Margaret Karow of Santa Rosa Valley CA (US)]]

==ADAM6 MICE - A simplified explanation of the abstract==


This abstract first appeared for US patent application 18597797 titled 'ADAM6 MICE

'''Simplified Explanation:'''
The patent application describes mice with modified ADAM6 activity, allowing them to generate offspring through mating.

'''Key Features and Innovation:'''
* Mice with reduced or deleted ADAM6 activity
* Ectopic ADAM6 sequence enabling male mice to reproduce
* Genetically modified immunoglobulin heavy chain loci with ADAM6 sequences

'''Potential Applications:'''
This technology could be used in genetic research, reproductive biology studies, and potentially in the development of new breeding strategies for mice.

'''Problems Solved:'''
This technology addresses the need for specific genetic modifications in mice for research purposes and potentially for breeding purposes.

'''Benefits:'''
* Enhanced understanding of ADAM6 function
* Potential for new breeding strategies in mice
* Advances in genetic research using modified mouse models

'''Commercial Applications:'''
Potential commercial applications could include the development of genetically modified mouse models for research institutions, pharmaceutical companies, and biotechnology firms.

'''Prior Art:'''
Readers interested in prior art related to this technology could explore research on genetic modifications in mice, reproductive biology, and ADAM6 function in mammals.

'''Frequently Updated Research:'''
Researchers may be conducting ongoing studies on the effects of modified ADAM6 activity in mice, as well as the implications for reproductive biology and genetic research.

'''Questions about ADAM6:'''
1. What are the potential implications of modified ADAM6 activity in male mice for breeding purposes?
2. How does the presence or absence of ADAM6 activity impact male mouse fertility?


==Original Abstract Submitted==

Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.



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