View source for 18435544. METHODS FOR MAKING L-GLUFOSINATE simplified abstract (BASF SE)

=METHODS FOR MAKING L-GLUFOSINATE=


==Organization Name==

[[:Category:BASF SE|BASF SE]]


[[Category:BASF SE]]

==Inventor(s)==

[[:Category:Brian Michael Green of Lutherville MD (US)|Brian Michael Green of Lutherville MD (US)]][[Category:Brian Michael Green of Lutherville MD (US)]]

[[:Category:Michelle Lorraine Gradley of Canterbury (GB)|Michelle Lorraine Gradley of Canterbury (GB)]][[Category:Michelle Lorraine Gradley of Canterbury (GB)]]

==METHODS FOR MAKING L-GLUFOSINATE - A simplified explanation of the abstract==


This abstract first appeared for US patent application 18435544 titled 'METHODS FOR MAKING L-GLUFOSINATE

The patent application describes methods for the production of L-glufosinate, also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid, through a two-step process.

* The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid).
* The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors.
* By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

Potential Applications:
- Production of L-glufosinate for agricultural use as a herbicide.
- Pharmaceutical applications for L-glufosinate in the treatment of certain medical conditions.

Problems Solved:
- Efficient production of L-glufosinate from D-glufosinate.
- Increased purity of L-glufosinate in the final product.

Benefits:
- Higher yield of L-glufosinate.
- Improved cost-effectiveness in the production process.

Commercial Applications:
- Agricultural industry for herbicide production.
- Pharmaceutical industry for drug development.

Questions about the technology:
1. How does the specific amination process improve the purity of L-glufosinate?
2. What are the potential environmental implications of using L-glufosinate as a herbicide?

Frequently Updated Research:
- Stay updated on advancements in the production of L-glufosinate for potential improvements in efficiency and yield.


==Original Abstract Submitted==

Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.



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