US Patent Application 18303533. SITE SPECIFIC GENETIC ENGINEERING UTILIZING TRANS-TEMPLATE RNAS simplified abstract
Contents
SITE SPECIFIC GENETIC ENGINEERING UTILIZING TRANS-TEMPLATE RNAS
Organization Name
Massachusetts Institute of Technology
Inventor(s)
Omar Abudayyeh of Cambridge MA (US)
Jonathan Gootenberg of Cambridge MA (US)
Kaiyi Jiang of Cambridge MA (US)
SITE SPECIFIC GENETIC ENGINEERING UTILIZING TRANS-TEMPLATE RNAS - A simplified explanation of the abstract
This abstract first appeared for US patent application 18303533 titled 'SITE SPECIFIC GENETIC ENGINEERING UTILIZING TRANS-TEMPLATE RNAS
Simplified Explanation
- The patent application describes compositions containing ttRNAs (template-transcript RNA) that can be used for editing and integrating polynucleotide sequences. - ttRNAs consist of a primer binding site, a reverse transcriptase template sequence, an aptamer, and an integration sequence with an integration site. - The method involves using ttRNAs to edit and integrate polynucleotide sequences. - The innovation allows for more efficient and precise editing and integration of polynucleotide sequences.
Original Abstract Submitted
Provided herein are compositions comprising, inter alia, a ttRNAs comprising (i) a primer binding site, (ii) a reverse transcriptase template sequence, (iii) an aptamer, and (iv) an integration sequence comprising an integration site. Also described herein are method of use of the ttRNAs in methods of editing and integrating polynucleotide sequences.
