US Patent Application 18028345. MULTIMERIC PROTEIN COMPLEXES AS ANTIBODY SUBSTITUTES FOR NEUTRALIZATION OF VIRAL PATHOGENS IN PROPHYLACTIC AND THERAPEUTIC APPLICATIONS simplified abstract

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MULTIMERIC PROTEIN COMPLEXES AS ANTIBODY SUBSTITUTES FOR NEUTRALIZATION OF VIRAL PATHOGENS IN PROPHYLACTIC AND THERAPEUTIC APPLICATIONS

Organization Name

The Regents of the University of California

Inventor(s)

Daniel L. Cox of San Francisco CA (US)

Richard L. Davis of Penn Valley PA (US)

Michael D. Toney of Davis CA (US)

MULTIMERIC PROTEIN COMPLEXES AS ANTIBODY SUBSTITUTES FOR NEUTRALIZATION OF VIRAL PATHOGENS IN PROPHYLACTIC AND THERAPEUTIC APPLICATIONS - A simplified explanation of the abstract

This abstract first appeared for US patent application 18028345 titled 'MULTIMERIC PROTEIN COMPLEXES AS ANTIBODY SUBSTITUTES FOR NEUTRALIZATION OF VIRAL PATHOGENS IN PROPHYLACTIC AND THERAPEUTIC APPLICATIONS

Simplified Explanation

The patent describes an engineered protein complex that can be used as a substitute for antibodies in treating viral infections, specifically COVID-19.

  • The protein complex is made up of human proteins and has a specific symmetry.
  • Each element of the protein complex contains a modified version of a human multimeric protein fused to a module containing multiple modified human beta solenoid proteins.
  • The modified protein complex is also fused to a pathogen binding domain derived from humans.
  • The patent also includes a separate antibody substitute composed of multiple pathogen binding domain complexes.
  • The invention can be used in both preventive and therapeutic treatments for viral infections, particularly for neutralizing the SARS-CoV-2 virus.


Original Abstract Submitted

The present patent consists of an engineered multimeric protein complex as antibody substitute composed of human proteins, with an m-fold symmetry, with each m-fold element containing a modified monomeric protein derived from a symmetric human multimeric protein complex fused to a module containing n fused, modified human beta solenoid proteins (mBSP), and that fused to a human derived pathogen binding domain (PBD), as well as a separate antibody substitute composed of P human PBD complexes. The invention may find application in prophylactic and therapeutic treatments for viral infections, especially for COVID19 by neutralizing the SARS-CoV-2 virus.

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