US Patent Application 17752302. Device And Method For Controlling And Configuring The Spacial And Temportal Evolution Of A Gradient In A MicroFluidic Environment simplified abstract
Device And Method For Controlling And Configuring The Spacial And Temportal Evolution Of A Gradient In A MicroFluidic Environment
Organization Name
Wisconsin Alumni Research Foundation
Inventor(s)
David J. Beebe of Madison WI (US)
Maria Virumbrales-munoz of Verona WI (US)
Cristina Sanchez De Diego of Madison WI (US)
Device And Method For Controlling And Configuring The Spacial And Temportal Evolution Of A Gradient In A MicroFluidic Environment - A simplified explanation of the abstract
This abstract first appeared for US patent application 17752302 titled 'Device And Method For Controlling And Configuring The Spacial And Temportal Evolution Of A Gradient In A MicroFluidic Environment
Simplified Explanation
The abstract describes a microfluidic platform that can control and configure the evolution of a gradient.
- The platform includes a plate with a chamber for holding cells or drug/reagent particles within a polymerized material.
- The platform also has multiple wells that can receive different types of media to create gradients in the polymerized material.
- The wells have two parts, one that connects to the outer surface of the plate and one that connects to the chamber.
- The cross-sectional areas of the wells are different, with the first part being larger than the second part.
- This design creates pinning valves in the second part of the wells, which help maintain the polymerized material in place.
- Overall, this microfluidic platform allows for precise control over the formation and configuration of gradients in the polymerized material.
Original Abstract Submitted
A microfluidic platform is provided for controlling and configuring the evolution of a gradient. The microfluidic platform includes a plate having an outer surface and defining a chamber therein for receiving cells and/or drug/reagent particles of interest captured within a polymerized material. A plurality of wells are adapted for receiving a one or more types of desired media to form gradients in the polymerized material. The plurality of wells have first portions communicating with the outer surface of the plate and second portions communicating with the chamber. The first and second portions of the plurality of wells having corresponding widths and cross-sectional areas, and each of the plurality of wells is spaced from an adjacent well of the plurality of wells by a distance. The cross-sectional areas of the first portions of the plurality of wells are greater than the cross-sectional areas of the second portions of the plurality of wells such that the second portions of the plurality of wells form pinning valves to maintain the material to be polymer.
