The Board of Trustees of the Leland Stanford Junior University patent applications published on November 30th, 2023

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Summary of the patent applications from The Board of Trustees of the Leland Stanford Junior University on November 30th, 2023

The Board of Trustees of the Leland Stanford Junior University has recently filed several patents covering a range of innovative technologies and methods. These patents demonstrate the organization's commitment to advancing various fields, including medical imaging, optical elements, asset tracking, cellular responses to mechanical force, liquid biopsy, innate immune response modulation, genome editing, implant complications prevention, and motion detection in MRI.

Summary: The patents filed by The Board of Trustees of the Leland Stanford Junior University include:

- A method for improving magnetic resonance imaging (MRI) using under-sampled k-space measurements, neural networks, and convex optimization techniques. - A diffractive optical element composed of multiple unit cells with phase elements arranged on a substrate. - Systems and methods for real-time global asset tracking using GPS/GNSS technology. - Thermo-responsive microbead compositions for studying cellular responses to mechanical force. - Using cell-free DNA from a liquid biopsy to track DNA from tumors and CAR T-cells, as well as predicting therapy response. - Compositions and methods for modulating the innate immune response using circular RNAs. - High-efficiency genome editing using retron-guide RNA cassettes and vectors. - Inhibitors of mechanotransduction to prevent complications associated with implants. - Detection of subject motion in MRI using Doppler radar.

Notable Applications: - Improving MRI image quality through under-sampled k-space measurements and neural networks. - Real-time global asset tracking using GPS/GNSS technology. - Simplified and efficient evaluation of cellular responses to mechanical force. - Liquid biopsy-based tracking and prediction of therapy response in cancer treatment. - Modulation of the innate immune response using circular RNAs. - High-efficiency genome editing for genetic disease prevention and treatment. - Prevention and treatment of complications associated with implants. - Noncontact motion detection in MRI using Doppler radar.

  • Improved MRI using under-sampled k-space measurements, neural networks, and convex optimization.
  • Diffractive optical element with arranged phase elements for optical applications.
  • Real-time global asset tracking using GPS/GNSS technology.
  • Thermo-responsive microbeads for studying cellular responses to mechanical force.
  • Liquid biopsy-based tracking and prediction of therapy response in cancer treatment.
  • Modulation of the innate immune response using circular RNAs.
  • High-efficiency genome editing using retron-guide RNA cassettes and vectors.
  • Inhibitors of mechanotransduction to prevent complications associated with implants.
  • Noncontact motion detection in MRI using Doppler radar.



Patent applications for The Board of Trustees of the Leland Stanford Junior University on November 30th, 2023

Non-contact MRI in-bore motion sensing method using CW Doppler radar with band-pass filtering (18202577)

Main Inventor

Wonje Lee


METHODS AND COMPOSITIONS FOR THE TREATMENT OF IMPLANT ASSOCIATED COMPLICATIONS (18029619)

Main Inventor

Geoffrey C. Gurtner


HIGH-THROUGHPUT PRECISION GENOME EDITING (18365040)

Main Inventor

Zachery Smith


CIRCULAR RNAS AND THEIR USE IN IMMUNOMODULATION (18176021)

Main Inventor

Howard Y. Chang


METHODS TO PREDICT OUTCOMES TO CHIMERIC ANTIGEN RECEPTOR T-CELLS IN LYMPHOMA FROM CELL-FREE DNA AND GENETIC MUTATIONS (18248757)

Main Inventor

David M. KURTZ


HIGH-THROUGHPUT FORCE-DEPENDENT CELLULAR RESPONSE ASSAY USING SPECTRALLY ENCODED SMART BEADS (18250723)

Main Inventor

Yinnian Feng


Systems and Methods for GPS/GNSS Based Real Time Global Asset Tracking (18321498)

Main Inventor

Barbara Ann Block


METHOD AND SYSTEM FOR GENERATION OF A NEEDLE-SHAPED BEAM BY A DIFFRACTIVE OPTICAL ELEMENT FOR USE IN EXTENDED DEPTH-OF-FOCUS OPTICAL COHERENCE TOMOGRAPHY ([[US Patent Application 18447094. METHOD AND SYSTEM FOR GENERATION OF A NEEDLE-SHAPED BEAM BY A DIFFRACTIVE OPTICAL ELEMENT FOR USE IN EXTENDED DEPTH-OF-FOCUS OPTICAL COHERENCE TOMOGRAPHY simplified abstract (The Board of Trustees of the Leland Stanford Junior University)|18447094]])

Main Inventor

Jingjing Zhao


Method for improving high frequency image features and details in deep learning MRI reconstructions (18202592)

Main Inventor

Shreyas S. Vasanawala